M
Michael J. Pugia
Researcher at Bayer Corporation
Publications - 31
Citations - 748
Michael J. Pugia is an academic researcher from Bayer Corporation. The author has contributed to research in topics: Dipstick & Reagent. The author has an hindex of 15, co-authored 31 publications receiving 722 citations.
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Journal ArticleDOI
Urinary protein and albumin excretion corrected by creatinine and specific gravity
TL;DR: A dipstick test plus an optical strip reader that can measure urine protein, albumin, and creatinine and calculate the appropriate ratios provides a better screening test for albuminuria or proteinuria than one measuring only albumin or protein.
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Nano-biosensor development for bacterial detection during human kidney infection: use of glycoconjugate-specific antibody-bound gold NanoWire arrays (GNWA)
Manju Basu,Sara Seggerson,Joshua Henshaw,Juan Jiang,Rocio del A. Cordona,Clare Lefave,Patrick J. Boyle,A.E. Miller,Michael J. Pugia,Subhash Basu +9 more
TL;DR: An efficient method for enhanced antibody binding has been developed with the covalent immobilization of an organic linker Dithiobissuccinimidylundecanoate on the GNWA surface for their ability to detect bacteria in clinical concentrations.
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Pathophysiology and diagnostic value of urinary trypsin inhibitors.
Michael J. Pugia,John A. Lott +1 more
TL;DR: The pathophysiology of an anti-inflammatory agent termed urinary trypsin inhibitor (uTi) is described, an important anti- inflammatory substance that is present in urine, blood and all organs, and bikunin, a selective inhibitor of serine proteases are described.
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High-sensitivity dye binding assay for albumin in urine.
TL;DR: A system that minimized nonspecific binding by the dye through the use of polymethyl vinyl ethers and bis‐(heptapropylene glycol) carbonate showed a greater chemical specificity for albumin when compared to most other proteins.
Journal ArticleDOI
Screening school children for albuminuria, proteinuria and occult blood with dipsticks.
Michael J. Pugia,John A. Lott,Junko Kajima,Takaaki Saambe,Miyuki Sasaki,Kooichi Kuromoto,Reiko Nakamura,Hisae Fusegawa,Yoshihide Ohta +8 more
TL;DR: The many reports on the association of albuminuria and risk of renal disease recommend that screening should be done for albumin rather than protein, and the cut-off for the albumin dipsticks probably should be set somewhat lower to reduce the number of false negatives and increase the sensitivity of the dipstick.