Michael J. Vasek

TL;DR: It is shown that viral infection of adult hippocampal neurons induces complement-mediated elimination of presynaptic terminals in a murine WNV neuroinvasive disease model, which provides a new murine model of WNV-induced spatial memory impairment, and identifies a potential mechanism underlying neurocognitive impairment in patients recovering from WNV Neuroinvasive Disease.

TL;DR: It is demonstrated that astrocytes also have sequence-dependent local translation in their peripheral processes, including transcripts with roles in regulating synapses, and one mechanism regulating this translation is identified, suggesting localtranslation inAstrocyte processes may play a role in synapse modulation.

TL;DR: It is shown, in a mouse model of West Nile virus–induced cognitive dysfunction, that neurogenesis is impaired by production of IL-1 from pro-inflammatory astrocytes, which might underlie the long-term cognitive consequences of WNND but also provides a therapeutic target.

TL;DR: The dual effects of voltage-sensitive dyes on GABAergic inhibition require caution in dye use for studies of excitability and network activity.

TL;DR: This work presents self-reporting transposons (SRTs) and uses scCC, which map SRTs from scRNA-seq libraries, simultaneously identifying cell types and TFBS in those same cells, establishing a new method for studying TF biology in situ.