J
Jinsheng Yu
Researcher at Washington University in St. Louis
Publications - 3
Citations - 493
Jinsheng Yu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 1, co-authored 1 publications receiving 340 citations.
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Journal ArticleDOI
A complement–microglial axis drives synapse loss during virus-induced memory impairment
Michael J. Vasek,Charise Garber,Denise A. Dorsey,Douglas M. Durrant,Douglas M. Durrant,Bryan Bollman,Allison Soung,Jinsheng Yu,Carlos J. Perez-Torres,Arnaud Frouin,Daniel K. Wilton,Kristen E. Funk,Bette K. DeMasters,Xiaoping Jiang,James R. Bowen,Steven Mennerick,John K. Robinson,Joel R. Garbow,Kenneth L. Tyler,Mehul S. Suthar,Robert E. Schmidt,Beth Stevens,Robyn S. Klein +22 more
TL;DR: It is shown that viral infection of adult hippocampal neurons induces complement-mediated elimination of presynaptic terminals in a murine WNV neuroinvasive disease model, which provides a new murine model of WNV-induced spatial memory impairment, and identifies a potential mechanism underlying neurocognitive impairment in patients recovering from WNV Neuroinvasive Disease.
Journal ArticleDOI
Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron
Zhenlu Chong,Courtney E. Karl,Peter Halfmann,Yoshihiro Kawaoka,Emma S. Winkler,Shamus P. Keeler,Michael J. Holtzman,Jinsheng Yu,Michael S. Diamond +8 more
TL;DR: In this article , the host-derived cytokine interferon lambda (IFN-λ) has been proposed as a possible treatment based on studies in human coronavirus 2019 (COVID-19) patients.
Journal ArticleDOI
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy
Alan J. Russell,Mike DuVall,Ben Barthel,Ying Qian,Angela K. Peter,Breanne L Newell-Stamper,Sarah J. Lehman,Stephen T. Schlachter,Benjamin D. Robertson,Ashleigh Van Deusen,Carlos Vera,Yu Su,Dennis R. Claflin,Susan V. Brooks,Peter P. Nghiem,Alexis M. Rutledge,Jinsheng Yu,Elisabeth R. Barton,Andreas Patsalos,H. Lee Sweeney,Leslie A. Leinwand +20 more
TL;DR: This article explored the role of fast skeletal muscle contraction in Duchenne muscular dystrophy with EDG-5506 and found that even modest decreases of contraction (<15%) were sufficient to protect skeletal muscles in dystrophic mdx mice from stress injury.