M
Michael Lisby
Researcher at University of Copenhagen
Publications - 127
Citations - 7688
Michael Lisby is an academic researcher from University of Copenhagen. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 40, co-authored 118 publications receiving 6809 citations. Previous affiliations of Michael Lisby include University of Texas at Austin & Columbia University.
Papers
More filters
Journal ArticleDOI
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
Journal ArticleDOI
Rad52 forms DNA repair and recombination centers during S phase
TL;DR: In this paper, the authors found that S. cerevisiae Rad52 fused to green fluorescent protein (GFP) is fully functional in DNA repair and recombination, after induction of DNA double-strand breaks by gamma-irradiation, meiosis, or HO endonuclease.
Journal ArticleDOI
Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre.
TL;DR: Analysis of DNA damage checkpoint-deficient cells provides direct evidence for coordination between DNA repair and subsequent release from checkpoint arrest and analyses of cells experiencing multiple DSBs demonstrate that Rad52 foci are centres of DNA repair capable of simultaneously recruiting more than one DSB.
Journal ArticleDOI
The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus
Jordi Torres-Rosell,Ivana Sunjevaric,Giacomo De Piccoli,Meik Sacher,Nadine Eckert-Boulet,Robert J.D. Reid,Stefan Jentsch,Rodney Rothstein,Luis Aragón,Michael Lisby +9 more
TL;DR: This study shows that recombinational repair of a DSB in rDNA in Saccharomyces cerevisiae involves the transient relocalization of the lesion to associate with the recombination machinery at an extranucleolar site and suggests a key role of sumoylation for nucleolar dynamics, perhaps in the compartmentalization of nuclear activities.
Journal ArticleDOI
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
TL;DR: Several models that have been proposed to explain the mechanism of mitotic recombination are discussed, the genes and proteins involved in various pathways, the genetic and physical assays used to discover and study these genes, and the roles of many of these proteins inside the cell are discussed.