M
Michael Lisby
Researcher at University of Copenhagen
Publications - 127
Citations - 7688
Michael Lisby is an academic researcher from University of Copenhagen. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 40, co-authored 118 publications receiving 6809 citations. Previous affiliations of Michael Lisby include University of Texas at Austin & Columbia University.
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A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts.
TL;DR: It is found that the TRe response relies on basal activity of the ATR kinase, yet it does not lead to hyperactivation of this key checkpoint protein, and specific abrogation of the T re response leads to DNA damage in mitosis, and promotes chromosome instability and cell death.
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The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line
Mohiuddin,Shunsuke Kobayashi,Islam Shamima Keka,Guillaume Guilbaud,Julian E. Sale,Takeo Narita,H. Ismail Abdel-Aziz,Xin Wang,Saki Ogawa,Hiroyuki Sasanuma,Roland K. Chiu,Vibe H. Oestergaard,Michael Lisby,Shunichi Takeda +13 more
TL;DR: Results suggest that HERC2 and RNF8 promote TLS past abasic sites and UV-lesions at or very close to stalled replication forks, and are both proficient in mono-ubiquitination of PCNA.
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Srs2 promotes Mus81–Mms4-mediated resolution of recombination intermediates
Melita Chavdarova,Victoria Marini,Alexandra Sisakova,Hana Sedlackova,Dana Vigasova,Dana Vigasova,Steven J. Brill,Michael Lisby,Lumir Krejci +8 more
TL;DR: The data point to a coordinated role of Mus81–Mms4 and Srs2 in processing of recombination as well as replication intermediates.
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The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress.
Emanuel Clausing,Andreas Mayer,Sittinan Chanarat,Barbara Müller,Susanne Manuela Germann,Patrick Cramer,Michael Lisby,Katja Strässer +7 more
TL;DR: A novel interaction between the transcription elongation factor Bur1-Bur2 and replication protein A (RPA), the eukaryotic single-stranded DNA-binding protein with functions in DNA repair, recombination, and replication is shown.
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Ethanol exposure increases mutation rate through error-prone polymerases.
Karin Voordeckers,Camilla Colding,Lavinia Grasso,Benjamin Pardo,Lore Hoes,Jacek Kominek,Jacek Kominek,Kim Gielens,Kaat Dekoster,Jonathan L Gordon,Elisa van der Zande,Peter W. Bircham,Toon Swings,Jan Michiels,Peter Van Loo,Peter Van Loo,Sandra Nuyts,Philippe Pasero,Michael Lisby,Kevin J. Verstrepen +19 more
TL;DR: Exposure to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate, which suggests that the mutagenic effect of ethanol depends on a complex mechanism, where dysfunctional replication forks lead to recruitment of error-prone polymerases.