M
Michael Mitchell
Researcher at Lincoln's Inn
Publications - 6
Citations - 2565
Michael Mitchell is an academic researcher from Lincoln's Inn. The author has contributed to research in topics: Gene & DNA repair. The author has an hindex of 6, co-authored 6 publications receiving 2455 citations. Previous affiliations of Michael Mitchell include Francis Crick Institute.
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Journal ArticleDOI
Human DNA Repair Genes
TL;DR: Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.
Journal ArticleDOI
Human DNA repair genes, 2005.
TL;DR: An updated inventory of about 150 human DNA repair genes is described, and the approximately 25 genes added, since the original version of the table was first produced in 2001, and some other revisions are discussed.
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A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.
Pei Juan Lu,Kristina Sundquist,Dan Baeckström,Richard Poulsom,Andrew M. Hanby,Sebastian Meier-Ewert,Tania A. Jones,Michael Mitchell,Paula M. Pitha-Rowe,Paul S. Freemont,Joyce Taylor-Papadimitriou +10 more
TL;DR: The presence of the dri motif and PHD/LAP fingers together with the clear nuclear localization and consistent expression in breast cancers, suggest a role for PLU-1 in regulating gene expression in Breast cancers.
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Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter.
Maria Ekerot,Marios P. Stavridis,Laurent Delavaine,Michael Mitchell,Christopher J. Staples,David M. Owens,Iain D. Keenan,Robin J. Dickinson,Kate G. Storey,Stephen M. Keyse +9 more
TL;DR: Findings identify a conserved Ets-factor-dependent mechanism by which ERK signalling activates DUSP6/MKP-3 transcription to deliver ERK1/2-specific negative-feedback control of FGF signalling.
Journal ArticleDOI
Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.
Teresa Iglesias,Noemí Cabrera-Poch,Michael Mitchell,Thomas J.P. Naven,Enrique Rozengurt,Giampietro Schiavo +5 more
TL;DR: It is shown that Kidins220 is an integral membrane protein selectively expressed in brain and neuroendocrine cells, where it concentrates at the tip of neurites and is phosphorylated by PKD at serine 919 in vivo.