M
Michael O. Dorschner
Researcher at University of Wisconsin–Milwaukee
Publications - 10
Citations - 1631
Michael O. Dorschner is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Genome & Chromatin. The author has an hindex of 7, co-authored 10 publications receiving 1588 citations. Previous affiliations of Michael O. Dorschner include University of Washington.
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Journal ArticleDOI
Mapping and sequencing of structural variation from eight human genomes
Jeffrey M. Kidd,Gregory M. Cooper,William F. Donahue,Hillary S. Hayden,Nick Sampas,Tina Graves,Nancy F. Hansen,Brian Teague,Can Alkan,Francesca Antonacci,Eric Haugen,Troy Zerr,N. Alice Yamada,Peter Tsang,Tera L. Newman,Eray Tüzün,Ze Cheng,Heather Ebling,Nadeem Tusneem,Robert David,Will D. Gillett,Karen A. Phelps,Molly Weaver,David J. Saranga,Adrianne Brand,Wei Tao,Erik Gustafson,Kevin McKernan,Lin Chen,Maika Malig,Joshua D. Smith,Joshua M. Korn,Steven A. McCarroll,David Altshuler,Daniel A. Peiffer,Michael O. Dorschner,John A. Stamatoyannopoulos,David C. Schwartz,Deborah A. Nickerson,James C. Mullikin,Richard K. Wilson,Laurakay Bruhn,Maynard V. Olson,Rajinder Kaul,Douglas R. Smith,Evan E. Eichler +45 more
TL;DR: This work employs a clone-based method to interrogate intermediate structural variation in eight individuals of diverse geographic ancestry and provides the first high-resolution sequence map of human structural variation—a standard for genotyping platforms and a prelude to future individual genome sequencing projects.
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Discovery of functional noncoding elements by digital analysis of chromatin structure
Peter J. Sabo,Michael Hawrylycz,James C. Wallace,Richard Humbert,Man Yu,Anthony Shafer,Janelle Kawamoto,Robert O. Hall,Joshua Mack,Michael O. Dorschner,Michael McArthur,John A. Stamatoyannopoulos +11 more
TL;DR: A quantitative methodology, digital analysis of chromatin structure (DACS), for high-throughput, automated mapping of DNase I-hypersensitive sites and associated cis-regulatory sequences in the human and other complex genomes is developed.
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High-throughput localization of functional elements by quantitative chromatin profiling
Michael O. Dorschner,Michael Hawrylycz,Richard Humbert,James C. Wallace,Anthony Shafer,Janelle Kawamoto,Joshua Mack,Robert Hall,Jeff Goldy,Peter J. Sabo,Ajay Kohli,Qiliang Li,Michael McArthur,John A. Stamatoyannopoulos +13 more
TL;DR: A generic approach, quantitative chromatin profiling, that uses quantitative analysis of in vivo chromatin structure over entire gene loci to rapidly and precisely localize cis-regulatory sequences and other functional modalities encoded by DNase I hypersensitive sites is described.
Journal ArticleDOI
The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1).
Adriana Donovan,Alison Brownlie,Michael O. Dorschner,Yi Zhou,Stephen J. Pratt,Barry H. Paw,Ruth B. Phillips,Christine Thisse,Bernard Thisse,Leonard I. Zon +9 more
TL;DR: The phenotype of chardonnay (cdy), a zebrafish mutant with hypochromic, microcytic anemia, is characterized and a nonsense mutation in the cdy allele is identified and it is demonstrated that, whereas wild-type zebra fish DMT1 protein can transport iron, the truncated protein expressed in cdy mutants is not functional.
Journal ArticleDOI
Sequence analysis of the mitochondrial DNA control region of ciscoes (genus Coregonus): Taxonomic implications for the Great Lakes species flock
TL;DR: The shortjaw cisco is not genetically distinct from other cisco species and high similarity within and among species and shared polymorphism for length variants is revealed.