M
Michael P. Barrett
Researcher at University of Glasgow
Publications - 332
Citations - 15731
Michael P. Barrett is an academic researcher from University of Glasgow. The author has contributed to research in topics: Trypanosoma brucei & Metabolomics. The author has an hindex of 65, co-authored 318 publications receiving 13859 citations. Previous affiliations of Michael P. Barrett include University of Bordeaux & Wellcome Trust.
Papers
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Journal ArticleDOI
Bestatin Induces Specific Changes in Trypanosoma cruzi Dipeptide Pool
Andrea Trochine,Andrea Trochine,Darren J. Creek,Paula Faral-Tello,Michael P. Barrett,Carlos Robello,Carlos Robello +6 more
TL;DR: After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.
Journal ArticleDOI
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.
Pieter C. Steketee,Emily A. Dickie,James Iremonger,Kathryn Crouch,Edith Paxton,Siddharth Jayaraman,Omar A. Alfituri,Georgina Awuah-Mensah,Ryan Ritchie,Achim Schnaufer,T.G Rowan,Harry P. de Koning,Catarina Gadelha,Bill Wickstead,Michael P. Barrett,Liam J. Morrison +15 more
TL;DR: In this article, a combination of omics technologies and novel genetic tools were used to characterise core metabolism in T. congolense mammalian-infective bloodstream-form parasites, and test whether metabolic differences compared to T. brucei impact upon sensitivity to metabolic inhibition.
Journal ArticleDOI
Inhibitors of Trypanosoma brucei 6-Phosphogluconate Dehydrogenase
Journal ArticleDOI
Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes.
Marco Biddau,T. R. Santha Kumar,Philipp P. Henrich,Larissa M. Laine,Gavin Blackburn,Achuthanunni Chokkathukalam,Tao Li,Kim Lee Sim,Lewis J King,Stephen L. Hoffman,Michael P. Barrett,Graham H. Coombs,Geoffrey I. McFadden,David A. Fidock,Sylke Müller,Lilach Sheiner +15 more
TL;DR: In this paper, a mutant Plasmodium falciparum (3D7 strain) lacking the apicoplast lipoic acid protein ligase B (lipB) known to be depleted of LA was analyzed.
Book ChapterDOI
Advances in Understanding and Treatment of Human African Trypanosomiasis: Divergent Diseases Caused by Distinct Parasites
TL;DR: Human African trypanosomiasis (HAT), often called sleeping sickness in its second, central nervous system–involved stage, is a disease of Sub-Saharan Africa caused by subspecies of the protozoan parasite Trypanosoma brucei, which is transmitted by tsetse flies.