M
Michael P. Barrett
Researcher at University of Glasgow
Publications - 332
Citations - 15731
Michael P. Barrett is an academic researcher from University of Glasgow. The author has contributed to research in topics: Trypanosoma brucei & Metabolomics. The author has an hindex of 65, co-authored 318 publications receiving 13859 citations. Previous affiliations of Michael P. Barrett include University of Bordeaux & Wellcome Trust.
Papers
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Journal ArticleDOI
A Colorimetric CMOS-Based Platform for Rapid Total Serum Cholesterol Quantification
Mohammed A. Al-Rawhani,Boon Chong Cheah,Alasdair I. MacDonald,Christopher Martin,Chunxiao Hu,James Beeley,Luiz Carlos Paiva Gouveia,James Grant,Gordon Campbell,Michael P. Barrett,David R. S. Cumming +10 more
TL;DR: A new disposable sensing platform that is based on a complementary metal oxide semiconductor process for total cholesterol quantification in pure blood serum is presented and it is shown that the quantification results are comparable to that obtained by a bench top spectrophotometer.
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Synthesis and biological evaluation of substrate-Based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African Trypanosomiasis
Christophe Dardonville,Eliana Rinaldi,Stefania Hanau,Michael P. Barrett,Reto Brun,Ian H. Gilbert +5 more
TL;DR: Three series of 6-phosphogluconate (6PG) analogues were synthesised and evaluated in vitro against T. brucei rhodesiense as well as other related trypanosomatid parasites.
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Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites
Alessandro Baliani,Alessandro Baliani,Valerie Peal,Ludovic Gros,Reto Brun,Marcel Kaiser,Michael P. Barrett,Ian H. Gilbert,Ian H. Gilbert +8 more
TL;DR: Most of the compounds tested in vitro for their trypanocidal activity showed activities in the submicromolar range against T. b.
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Hexose uptake in Trypanosoma cruzi: structure-activity relationship between substrate and transporter.
TL;DR: The gene encoding a hexose transporter, TcrHt1, from Trypanosoma cruzi has been functionally expressed in mammalian Chinese hamster ovary cells, confirming that TcrHT1 is the major transporter functioning in these parasites.
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Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.
Rachel L. Clark,Carol Clements,Michael P. Barrett,Simon P. Mackay,Rajendra P. Rathnam,George Owusu-Dapaah,John Spencer,John Spencer,Judith K. Huggan +8 more
TL;DR: A library of 1,4-benzodiazepines has been synthesised and evaluated for activity against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis (HAT).