Michael Rubart

TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.

TL;DR: Investigation of the ability of transplanted BM cells to develop intracellular calcium transients in response to membrane depolarization in situ concludes that engrafted BM-derived cells lack attributes of functioning cardiomyocytes, calling into question the concept that adult BM cells can give rise to substantiveCardiomyocyte regeneration within the infarcted heart.

TL;DR: FKPB12-mediated dysregulation of INa may underlie clinical arrhythmias associated with FK506 administration and is important for cardiac arrh rhythmogenic physiology.

TL;DR: It is highlighted that positive identification based upon one parameter alone such as morphology or immunofluorescene is not adequate to identify the source, fate and function of adult cardiac explant derived cells.

TL;DR: In this paper, the authors used two-photon laser scanning microscopy in conjunction with a voltage-sensitive dye to record transmembrane voltage changes simultaneously from cardiomyocytes and adjoined nonmyocytes in Langendorff-perfused mouse heart with healing myocardial infarction.