D
David A. Williams
Researcher at Indiana University – Purdue University Indianapolis
Publications - 13
Citations - 2842
David A. Williams is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 6, co-authored 13 publications receiving 2793 citations. Previous affiliations of David A. Williams include Cincinnati Children's Hospital Medical Center & Riley Hospital for Children.
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Journal ArticleDOI
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry,Mark H. Soonpaa,Hans Reinecke,Hidehiro Nakajima,Hisako O. Nakajima,Michael Rubart,Kishore B.S. Pasumarthi,Kishore B.S. Pasumarthi,Jitka A. I. Virag,Stephen H. Bartelmez,Veronica Poppa,Gillian Bradford,Joshua D. Dowell,David A. Williams,David A. Williams,Loren J. Field +15 more
TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.
Journal ArticleDOI
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
Feng Chun Yang,Simon J. Atkinson,Ying Gu,Ying Gu,Jovencio Borneo,Jovencio Borneo,Andrew W. Roberts,Andrew W. Roberts,Andrew W. Roberts,Yi Zheng,Janice G. Pennington,David A. Williams,David A. Williams +12 more
TL;DR: This genetic analysis provides physiological evidence of cross-talk between GTPase proteins and suggests that a balance of these two GTPases controls HSC/P adhesion and mobilization in vivo.
Journal ArticleDOI
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
Ben A. Croker,David M. Tarlinton,Leonie A. Cluse,Alana J. Tuxen,Amanda Light,Feng Chun Yang,David A. Williams,Andrew W. Roberts +7 more
TL;DR: Rac2 is an essential element in regulating B lymphocyte functions and maintaining B lymphocytes populations in vivo and T cell-independent responses to DNP-dextran were of reduced magnitude, but normal kinetics in rac2−/− mice.
Journal Article
Activation of the Epidermal Platelet-Activating Factor Receptor Results in Cytokine and Cyclooxygenase-2 Biosynthesis
Yong Pei,Lisa A. Barber,Robert C. Murphy,Christopher A. Johnson,Susan W. Kelley,Lady C. Dy,Richard H. Fertel,Thanh Minh Nguyen,David A. Williams,Jeffrey B. Travers +9 more
TL;DR: Involvement of PAF and the PAF-R in the epidermal cytokine network is suggested, indicating the existence of a positive feedback loop between IL-8 and PAF inEpidermal cells.
Journal ArticleDOI
Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
Rodney Maze,James P. Carney,Mark R. Kelley,Brian J. Glassner,David A. Williams,David A. Williams,Leona D. Samson +6 more
TL;DR: It is demonstrated that increased DNA alkylation repair in primitive hematopoietic stem cells confers multilineage protection from the myelosuppressive effects of BCNU and suggest a possible approach to protecting cancer patients from CNU chemotherapy-related toxicity.