Journal ArticleDOI
Breaching multiple barriers : Leukocyte motility through venular walls and the interstitium
TLDR
Emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.Abstract:
The shuttling of leukocytes between the bloodstream and interstitial tissues involves different locomotion strategies that are governed by locally presented soluble and cell-bound signals. Recent studies have furthered our understanding of the rapidly advancing field of leukocyte migration, particularly regarding cellular and subcellular events at the level of the venular wall. Furthermore, emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.read more
Citations
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Journal ArticleDOI
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
Book ChapterDOI
Cell Biology of Ischemia/Reperfusion Injury
TL;DR: It is apparent that a combination of molecular and cellular approaches targeting multiple pathologic processes to limit the extent of I/R injury must be adopted to enhance resistance to cell death and increase regenerative capacity in order to effect long-lasting repair of ischemic tissues.
Journal ArticleDOI
Leukocyte migration into inflamed tissues.
Sussan Nourshargh,Ronen Alon +1 more
TL;DR: Current knowledge and open questions regarding the mechanisms involved in the interactions of different effector leukocytes with peripheral vessels in extralymphoid organs are discussed.
Journal ArticleDOI
The impact of the extracellular matrix on inflammation.
TL;DR: In chronically inflamed tissues, aberrant ECM expression and fragments of the ECM that are derived from tissue-remodelling processes can influence immune cell activation and survival, thereby actively contributing to immune responses at these sites.
Journal ArticleDOI
Neutrophils at work
TL;DR: This Review examines in vivo observations of the recruitment of neutrophils from blood to tissues in models of blood-borne infections versus bacterial invasion through epithelial linings, and examines data on novel aspects of the activation of NADPH oxidase and the heterogeneity of phagosomes.
References
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Journal ArticleDOI
Getting to the site of inflammation: the leukocyte adhesion cascade updated
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Journal ArticleDOI
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Sarah J. Heasman,Anne J. Ridley +1 more
TL;DR: The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development.
Journal ArticleDOI
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
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Journal ArticleDOI
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
TL;DR: GEFs and GAPs are multidomain proteins that are regulated by extracellular signals and localized cues that control cellular events in time and space and are potential therapeutic targets for developing drugs to treat various diseases, including cancer.