Michael W. Nestor

TL;DR: Overexpression of wild-type GBA and treatment with MAO-B inhibitors normalized α-synuclein and dopamine levels, suggesting a combination therapy for the affected twin.

TL;DR: Improvements to the oocyte activation protocol are shown to promote development to the blastocyst stage, and diploid pluripotent stem-cell lines are derived from somatic cells of a newborn and, for the first time, an adult, a female with type 1 diabetes.

TL;DR: In this model, induced pluripotent stem cells from affected and unaffected individuals from two families carrying PSEN1 mutations are generated and an essential feature in the molecular pathogenesis of FAD is reconstituted, increased generation of Aβ42/40, and has characterized novel expression changes.

TL;DR: The importance of properly evaluating the electrophysiological status of the newly generated neurons when using stem cell technology is demonstrated, as electrophYSiological properties of iPSC-derived neurons mature over time.

TL;DR: Using serum-free embryoid bodies generated from human inducible pluripotent stem cells (iPSCs), it is demonstrated that these interneuron progenitors exhibit morphological, immunocytochemical, and electrophysiological hallmarks of developing cortical interneurons.