S
Scott Noggle
Researcher at New York Stem Cell Foundation
Publications - 82
Citations - 5687
Scott Noggle is an academic researcher from New York Stem Cell Foundation. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 31, co-authored 74 publications receiving 4601 citations. Previous affiliations of Scott Noggle include Georgia Regents University & University of Georgia.
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Journal ArticleDOI
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
Dominik Paquet,Dylan Kwart,Antonia F. Chen,Andrew A. Sproul,Samson T. Jacob,Shaun Teo,Kimberly Moore Olsen,Andrew Gregg,Andrew Gregg,Scott Noggle,Marc Tessier-Lavigne +10 more
TL;DR: A CRISPR/Cas9-based genome-editing framework that allows selective introduction of mono- and bi-allelic sequence changes with high efficiency and accuracy is described and HDR accuracy is increased dramatically, and a method termed ‘CORRECT’ for scarless genome editing is established.
Journal ArticleDOI
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Evangelos Kiskinis,Evangelos Kiskinis,Evangelos Kiskinis,Jackson Sandoe,Jackson Sandoe,Jackson Sandoe,Luis A. Williams,Luis A. Williams,Luis A. Williams,Gabriella L. Boulting,Gabriella L. Boulting,Rob Moccia,Rob Moccia,Rob Moccia,Brian J. Wainger,Brian J. Wainger,Steve S.W. Han,Steve S.W. Han,Steve S.W. Han,Theodore Peng,Theodore Peng,Theodore Peng,Sebastian Thams,Shravani Mikkilineni,Shravani Mikkilineni,Shravani Mikkilineni,Cassidy Mellin,Florian T. Merkle,Florian T. Merkle,Florian T. Merkle,Brandi N. Davis-Dusenbery,Brandi N. Davis-Dusenbery,Brandi N. Davis-Dusenbery,Michael J. Ziller,Derek H. Oakley,Justin K. Ichida,Justin K. Ichida,Stefania Di Costanzo,Stefania Di Costanzo,Nick Atwater,Nick Atwater,Nick Atwater,Morgan L. Maeder,Mathew J. Goodwin,James Nemesh,James Nemesh,James Nemesh,Robert E. Handsaker,Robert E. Handsaker,Robert E. Handsaker,Daniel Paull,Scott Noggle,Steven A. McCarroll,Steven A. McCarroll,Steven A. McCarroll,J. Keith Joung,Clifford J. Woolf,Robert H. Brown,Kevin Eggan,Kevin Eggan,Kevin Eggan +60 more
TL;DR: Reprogramming and stem cell differentiation approaches with genome engineering and RNA sequencing are combined to define the transcriptional and functional changes that are induced in human motor neurons by mutant SOD1, indicating that at least a subset of these changes are more broadly conserved in ALS.
Journal ArticleDOI
A viral strategy for targeting and manipulating interneurons across vertebrate species
Jordane Dimidschstein,Jordane Dimidschstein,Qian Chen,Robin Tremblay,Stephanie L. Rogers,Giuseppe A. Saldi,Lihua Guo,Lihua Guo,Qing Xu,Qing Xu,Runpeng Liu,Congyi Lu,Jianhua Chu,Joshua S. Grimley,Anne-Rachel F. Krostag,Ajamete Kaykas,Michael C. Avery,Mohammad S. Rashid,Myungin Baek,Amanda L. Jacob,Gordon B. Smith,Daniel E. Wilson,Georg Kosche,Illya Kruglikov,Tomasz Rusielewicz,Vibhakar C. Kotak,Todd M. Mowery,Stewart A. Anderson,Edward M. Callaway,Jeremy S. Dasen,David Fitzpatrick,Valentina Fossati,Michael A. Long,Scott Noggle,John V. Reynolds,Dan H. Sanes,Bernardo Rudy,Guoping Feng,Guoping Feng,Gord Fishell,Gord Fishell +40 more
TL;DR: In this article, a recombinant adeno-associated virus that restricts gene expression to GABAergic interneurons within the telencephalon was proposed to study brain function in both mice and non-genetically tractable species.
Journal ArticleDOI
Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture.
Thomas C. Schulz,Scott Noggle,Scott Noggle,Gail M. Palmarini,Deb A. Weiler,Ian Lyons,Kate A. Pensa,Adrian Cuda Banda Meedeniya,Bruce Davidson,Nevin A. Lambert,Nevin A. Lambert,Brian G. Condie +11 more
TL;DR: This work suggests that hESCs can differentiate in simple serum‐free suspension cultures to produce the large number of cells required for transplantation studies.
Journal ArticleDOI
Human Embryonic Stem Cell Lines Derived from Discarded Embryos
Maisam Mitalipova,John D. Calhoun,Soojung Shin,David Wininger,Thomas C Schulz,Scott Noggle,Scott Noggle,Alison Venable,Ian Lyons,Allan J. Robins,Steven L. Stice +10 more
TL;DR: Four human pluripotent embryonic stem cells are derived from poor‐quality embryos that in the course of routine clinical practice would have been discarded, and maintained their developmental potential to form trophoblast and somatic cells, including cardiac muscle and neuronal tissue.