J
John W. Steele
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 13
Citations - 809
John W. Steele is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Latrepirdine & Amyloid beta. The author has an hindex of 10, co-authored 13 publications receiving 731 citations.
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Journal ArticleDOI
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.
Andrew A. Sproul,Samson T. Jacob,Deborah Pre,Soong Ho Kim,Michael W. Nestor,Miriam Navarro-Sobrino,Ismael Santa-Maria,Matthew Zimmer,Soline Aubry,John W. Steele,David J. Kahler,Alex Dranovsky,Ottavio Arancio,John F. Crary,Sam Gandy,Scott Noggle +15 more
TL;DR: In this model, induced pluripotent stem cells from affected and unaffected individuals from two families carrying PSEN1 mutations are generated and an essential feature in the molecular pathogenesis of FAD is reconstituted, increased generation of Aβ42/40, and has characterized novel expression changes.
Journal ArticleDOI
Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex
Rachel F Lane,Summer M. Raines,John W. Steele,Michelle E. Ehrlich,James A. Lah,Scott A. Small,Rudolph E. Tanzi,Alan D. Attie,Sam Gandy +8 more
TL;DR: SorCS1 and SorL1/SorLA/LR11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) domain-containing proteins as mentioned in this paper.
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Days-to-criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers
Sam Gandy,Adam J. Simon,John W. Steele,Alex L. Lublin,James J. Lah,Lary C. Walker,Lary C. Walker,Allan I. Levey,Grant A. Krafft,Efrat Levy,Efrat Levy,Frédéric Checler,Charles G. Glabe,Warren B. Bilker,Ted Abel,James Schmeidler,Michelle E. Ehrlich +16 more
TL;DR: This work sought to study the bioactivities of endogenously formed oAβ/ADDLs generated in situ from the physiological processing of human amyloid precursor protein (APP) and presenitin1 (PS1) transgenes.
Journal ArticleDOI
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
John W. Steele,M. L. Lachenmayer,M. L. Lachenmayer,Shulin Ju,Aryeh Stock,J. Liken,Soong Ho Kim,Luz Delgado,Iván E. Alfaro,Sebastian Bernales,Giuseppe Verdile,Prashant Bharadwaj,Veer Bala Gupta,Renae Barr,A. Friss,Georgia Dolios,Rong Wang,Dagmar Ringe,Paul E. Fraser,David Westaway,P. St. George-Hyslop,Paul Szabo,Norman R. Relkin,Joseph D. Buxbaum,Charles G. Glabe,Charles G. Glabe,Andrew Asher Protter,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins,Michelle E. Ehrlich,Gregory A. Petsko,Gregory A. Petsko,Zhenyu Yue,Sam Gandy,Sam Gandy +35 more
TL;DR: It is concluded that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases.
Journal ArticleDOI
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain
John W. Steele,Shulin Ju,M.L. Lachenmayer,M.L. Lachenmayer,J. Liken,Aryeh Stock,Soong Ho Kim,Luz Delgado,Iván E. Alfaro,Sebastian Bernales,Giuseppe Verdile,Prashant Bharadwaj,Veer Bala Gupta,Renae Barr,A. Friss,Georgia Dolios,Rong Wang,Dagmar Ringe,Andrew Asher Protter,Ralph N. Martins,Ralph N. Martins,Ralph N. Martins,Michelle E. Ehrlich,Zhenyu Yue,Gregory A. Petsko,Gregory A. Petsko,Sam Gandy,Sam Gandy +27 more
TL;DR: It is proposed that latrepirdine may represent a novel scaffold for discovery of robust pro-autophagic/anti-neurodegeneration compounds, which might yield clinical benefit for synucleinopathies including Parkinson's disease, Lewy body dementia, rapid eye movement (REM) sleep disorder and/or multiple system atrophy, following optimization of its pro- autophagic and pro-NEurogenic activities.