Soong Ho Kim

TL;DR: In this model, induced pluripotent stem cells from affected and unaffected individuals from two families carrying PSEN1 mutations are generated and an essential feature in the molecular pathogenesis of FAD is reconstituted, increased generation of Aβ42/40, and has characterized novel expression changes.

TL;DR: It is concluded that LAT possesses pro-autophagic properties in addition to the previously reported pro-neurogenic properties, both of which are potentially relevant to the treatment and/or prevention of neurodegenerative diseases.

TL;DR: It is proposed that latrepirdine may represent a novel scaffold for discovery of robust pro-autophagic/anti-neurodegeneration compounds, which might yield clinical benefit for synucleinopathies including Parkinson's disease, Lewy body dementia, rapid eye movement (REM) sleep disorder and/or multiple system atrophy, following optimization of its pro- autophagic and pro-NEurogenic activities.

TL;DR: Assessment of the therapeutic potential of chronic pharmacological inhibition of Group II mGluR in Dutch APP transgenic mice found it to offer a unique package of relevant properties as an Alzheimer’s disease therapeutic or prophylactic by providing both attenuation of neuropathology and stimulation of repair.

TL;DR: Levels of the amyloid precursor protein (APP) were increased following blast exposure although there was no evidence of axonal pathology based on APP immunohistochemical staining and strategies aimed at lowering Aβ production may not be effective for treating acute blast injury to the brain.