Michael Willem

TL;DR: It is found that very high levels of BACE1 were expressed at time points when peripheral nerves become myelinated and correct bundling of axons by Schwann cells, probably through processing of type III NRG1.

TL;DR: It is reported that missense mutations associated with FTD and FTD-like syndrome reduce TREM2 maturation, abolish shedding by ADAM proteases, and impair the phagocytic activity of TREM1-expressing cells.

TL;DR: It is demonstrated that treatment of zebrafish embryos with a known γ‐secretase inhibitor affects embryonic development in a manner indistinguishable from Notch signaling deficiencies at morphological, molecular and biochemical levels, which indicates severe side‐effects of γ-secretase inhibitors in any Notch‐dependent cell fate decision and demonstrates that the zebra fish is an ideal vertebrate system to validate compounds that selectively affect Aβ production, but not Notch signalling, under in vivo conditions.

TL;DR: Homing behavior and function of autoimmune CD4+ T cells in vivo was analyzed before and during EAE, using MBP-specific T cells retrovirally engineered to express the gene of green fluorescent protein.

TL;DR: A new physiological APP processing pathway is described, which generates proteolytic fragments capable of inhibiting neuronal activity within the hippocampus, and this finding may also indicate potential translational relevance for therapeutic strategies targeting APP processing.