M
Michele Boiani
Researcher at Max Planck Society
Publications - 82
Citations - 6000
Michele Boiani is an academic researcher from Max Planck Society. The author has contributed to research in topics: Embryonic stem cell & Blastocyst. The author has an hindex of 26, co-authored 76 publications receiving 5646 citations. Previous affiliations of Michele Boiani include University of Pennsylvania & University of Pavia.
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Journal ArticleDOI
Derivation of oocytes from mouse embryonic stem cells
Karin Hübner,Guy Fuhrmann,Lane K. Christenson,James Kehler,Rolland Reinbold,Rabindranath De La Fuente,Jennifer R. Wood,Jerome F. Strauss,Michele Boiani,Hans R. Schöler +9 more
TL;DR: It is shown that mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop into blastocysts.
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5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming
Mark Wossidlo,Toshinobu Nakamura,Konstantin Lepikhov,C. Joana Marques,Valeri Zakhartchenko,Michele Boiani,Julia Arand,Toru Nakano,Wolf Reik,Wolf Reik,Jörn Walter +10 more
TL;DR: The data suggest an important role of 5hmC and Tet3 for DNA methylation reprogramming processes in the mammalian zygote, as detected in mouse, bovine and rabbit zygotes.
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Regulatory networks in embryo-derived pluripotent stem cells.
Michele Boiani,Hans R. Schöler +1 more
TL;DR: In this paper, the regulatory networks that are responsible for pluripotency in embryo-derived stem cells are investigated and the authors reveal how to achieve phenotypic changes without the genetic manipulation of OCT4, Nanog and other toti/pluripotent associated genes.
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Oct4 is required for primordial germ cell survival
James Kehler,E. N. Tolkunova,Birgit Koschorz,Maurizio Pesce,Luca Gentile,Michele Boiani,Hilda Lomelí,Hilda Lomelí,Andras Nagy,K. John McLaughlin,Hans R. Schöler,Hans R. Schöler,Alexey Tomilin,Alexey Tomilin +13 more
TL;DR: A previously unknown function of Oct4 in maintaining viability of mammalian germline is suggested using the conditional Cre/loxP gene targeting strategy to assess Oct4 function in primordial germ cells (PGCs).
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Oct4 distribution and level in mouse clones: consequences for pluripotency
TL;DR: The quality of GFP signals in blastocysts correlated with the ability to generate outgrowths that maintain GFP expression and the frequency of embryonic stem (ES) cell derivation, and the variations observed in Oct4 levels alone account for the majority of failures currently observed for somatic cell cloning.