M
Michele Carbone
Researcher at University of Hawaii
Publications - 225
Citations - 15866
Michele Carbone is an academic researcher from University of Hawaii. The author has contributed to research in topics: Mesothelioma & Cancer. The author has an hindex of 64, co-authored 216 publications receiving 14106 citations. Previous affiliations of Michele Carbone include University of Hawaii at Manoa & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Germline BAP1 mutations predispose to malignant mesothelioma
Joseph R. Testa,Mitchell Cheung,Jianming Pei,Jennifer E. Below,Yinfei Tan,Eleonora Sementino,Nancy J. Cox,A. Umran Dogan,A. Umran Dogan,Harvey I. Pass,Sandra Trusa,Mary Hesdorffer,Masaki Nasu,Amy Powers,Zeyana Rivera,Sabahattin Cömertpay,Mika Tanji,Giovanni Gaudino,Haining Yang,Michele Carbone +19 more
TL;DR: A BAP1-related cancer syndrome is identified that is characterized by mesothelioma and uveal melanoma, and it is hypothesized that other cancers may also be involved and that mesot helioma predominates upon asbestos exposure.
Journal ArticleDOI
Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients.
Raja M. Flores,Harvey I. Pass,Venkatraman E. Seshan,Joseph Dycoco,Maureen F. Zakowski,Michele Carbone,Manjit S. Bains,Valerie W. Rusch +7 more
TL;DR: Patients who underwent pleurectomy/decortication had a better survival than those who underwent extrapleural pneumonectomy; however, the reasons are multifactorial and subject to selection bias.
Journal ArticleDOI
BAP1 and cancer
TL;DR: Findings indicate that germline BAP1 mutations cause a novel cancer syndrome that is characterized by the onset at an early age of benign melanocytic skin tumours with mutated B AP1, and later in life by a high incidence of mesothelioma, uveal melanoma, cutaneous melanoma and possibly additional cancers.
Journal Article
Simian virus 40-like DNA sequences in human pleural mesothelioma.
Michele Carbone,Harvey I. Pass,Paola Rizzo,M. Marinetti,M. Di Muzio,Daphne J. Y. Mew,Arthur S. Levine,Antonio Domenico Procopio +7 more
TL;DR: It is suggested that a simian virus 40-like virus may act independently or as a co-carcinogen with asbestos, and the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.
Journal ArticleDOI
The pathogenesis of mesothelioma
TL;DR: The capacity of T-antigen to bind and inhibit cellular p53 and retinoblastoma (Rb)-family proteins in mesothelioma, together with the very high susceptibility of human mesothelial cells to SV40-mediated transformation in vitro, supports a causative role of SV40 in the pathogenesis of mesotHelioma.