Y
Yinfei Tan
Researcher at Fox Chase Cancer Center
Publications - 30
Citations - 1541
Yinfei Tan is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Protein kinase B & Medicine. The author has an hindex of 13, co-authored 23 publications receiving 1220 citations.
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Journal ArticleDOI
Germline BAP1 mutations predispose to malignant mesothelioma
Joseph R. Testa,Mitchell Cheung,Jianming Pei,Jennifer E. Below,Yinfei Tan,Eleonora Sementino,Nancy J. Cox,A. Umran Dogan,A. Umran Dogan,Harvey I. Pass,Sandra Trusa,Mary Hesdorffer,Masaki Nasu,Amy Powers,Zeyana Rivera,Sabahattin Cömertpay,Mika Tanji,Giovanni Gaudino,Haining Yang,Michele Carbone +19 more
TL;DR: A BAP1-related cancer syndrome is identified that is characterized by mesothelioma and uveal melanoma, and it is hypothesized that other cancers may also be involved and that mesot helioma predominates upon asbestos exposure.
Journal ArticleDOI
Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Jinfei Xu,Yuwaraj Kadariya,Mitchell Cheung,Jianming Pei,Jacqueline Talarchek,Eleonora Sementino,Yinfei Tan,Craig W. Menges,Kathy Q. Cai,Samuel Litwin,Hongzhuang Peng,Jayashree Karar,Frank J. Rauscher,Joseph R. Testa +13 more
TL;DR: Unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
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Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
Alexander Beatty,Tanu Singh,Yulia Y. Tyurina,Vladimir A. Tyurin,S. N. Samovich,Emmanuelle Nicolas,Kristen Maslar,Yan Zhou,Kathy Q. Cai,Yinfei Tan,Sebastian Doll,Marcus Conrad,Aravind Subramanian,Hülya Bayır,Valerian E. Kagan,Ulrike Rennefahrt,Jeffrey R. Peterson +16 more
TL;DR: In this paper, conjugated linoleates including α-eleostearic acid (αESA) were identified as inducers of cancer cell death in different cancer cell types.
Journal ArticleDOI
Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling
TL;DR: Stable knockdown of DLX5 by lentivirus-mediated transduction of short hairpin RNA resulted in reduced proliferation of ovarian cancer cells due to inhibition of cell cycle progression in connection with the downregulation of cyclins A, B 1, D1, D2, and E, and decreased phosphorylation of AKT.
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Appl1 Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts
TL;DR: The studies suggest that Appl1 is dispensable for development and only participate in Akt signaling under certain conditions, and it is found that Appl proteins are required for HGF-induced cell survival and migration via activation of Akt.