Zeyana Rivera

TL;DR: A BAP1-related cancer syndrome is identified that is characterized by mesothelioma and uveal melanoma, and it is hypothesized that other cancers may also be involved and that mesot helioma predominates upon asbestos exposure.

TL;DR: These findings identify the release of HMGB1 as a critical initial step in the pathogenesis of asbestos-related disease, and provide mechanistic links between asbestos-induced cell death, chronic inflammation, and carcinogenesis.

TL;DR: It is shown that HMGB1 establishes an autocrine circuit in malignant mesothelioma cells that influences their proliferation and survival, and it is offered a preclinical proof-of-principle that antibody-mediated ablation of HMBG1 is sufficient to elicit therapeutic activity, suggesting a novel therapeutic approach for malignant asbestos-related cancer treatment.

TL;DR: The findings indicate that implementation of novel preventive and early detection programs in ND and other erionite-rich areas of the United States, similar to efforts currently being undertaken in Turkey, is warranted.

TL;DR: The results establish the safety of CSPG4 mAb-based immunotherapy and suggest that C SPG4mAb- based immunotherapy may represent a novel approach for the treatment of MM.