M
Michele L. Okun
Researcher at University of Colorado Colorado Springs
Publications - 74
Citations - 5717
Michele L. Okun is an academic researcher from University of Colorado Colorado Springs. The author has contributed to research in topics: Pregnancy & Sleep disorder. The author has an hindex of 32, co-authored 64 publications receiving 4981 citations. Previous affiliations of Michele L. Okun include University of Colorado Denver & University of Pittsburgh.
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Journal ArticleDOI
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.
Emmanuel Mignot,Gert Jan Lammers,Beth Ripley,Michele L. Okun,Sonia Nevsimalova,Sebastiaan Overeem,Jitka Vankova,Jed Black,John R. Harsh,Claudio L. Bassetti,Harald Schrader,Seiji Nishino +11 more
TL;DR: Measuring CSF hypocretin-1 is a definitive diagnostic test, provided that it is interpreted within the clinical context, in cases with cataplexy and when the MSLT is difficult to interpret (ie, in subjects already treated with psychoactive drugs or with other concurrent sleep disorders).
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Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups
Emmanuel Mignot,Ling Lin,William J. Rogers,Yutaka Honda,Xiaohong Qiu,X. Lin,Michele L. Okun,Hirohiko Hohjoh,Tetsuro Miki,Susan H. Hsu,Mary S. Leffell,F. Carl Grumet,Marcelo Fernandez-Vina,Makoto Honda,Neil Risch +14 more
TL;DR: Findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy and indicate that complex HLA-DR and -DQ interactions contribute to the genetic predisposition to human narCOlepsy but that additional susceptibility loci are also most likely involved.
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Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy
TL;DR: Elevated stress levels across pregnancy were predictive of elevated production of the pro-inflammatory cytokines IL-1B and IL-6 by stimulated lymphocytes in the 3rd trimester, suggesting that stress during pregnancy affects the function of immune system cells.
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Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
Seiji Nishino,Beth Ripley,Sebastiaan Overeem,Sebastiaan Overeem,Sona Nevsimalova,Gert Jan Lammers,Jitka Vankova,Michele L. Okun,William J. Rogers,Stephen N. Brooks,Emmanuel Mignot +10 more
TL;DR: It is concluded that the hypocretin ligand is deficient in most cases of human narcolepsy, providing possible diagnostic applications and increased BMI and leptin indicate altered energy homeostasis.
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Prenatal stress alters cytokine levels in a manner that may endanger human pregnancy.
TL;DR: These findings provide initial support for the hypothesis that stress-related neural immune interactions may contribute to pregnancy complications and poor outcome, but require further study to determine the mechanism and significance of these effects.