M
Michele Tonelli
Researcher at University of Genoa
Publications - 53
Citations - 1200
Michele Tonelli is an academic researcher from University of Genoa. The author has contributed to research in topics: Virus & Pharmacophore. The author has an hindex of 18, co-authored 47 publications receiving 916 citations.
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Journal ArticleDOI
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Michele Tonelli,Matteo Simone,Bruno Tasso,Federica Novelli,Vito Boido,Fabio Sparatore,Giuseppe Paglietti,Sabrina Pricl,Gabriele Giliberti,Sylvain Blois,Cristina Ibba,Giuseppina Sanna,Roberta Loddo,Paolo La Colla +13 more
TL;DR: The considered compounds represent attractive leads for the development of antiviral agents against poxviruses, pestiviruses and even HCV, which are important human and veterinary pathogens.
Journal ArticleDOI
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives
Michele Tonelli,I. Vazzana,Bruno Tasso,Vito Boido,Fabio Sparatore,Maurizio Fermeglia,Maria Silvia Paneni,Paola Posocco,Sabrina Pricl,Paolo La Colla,Cristina Ibba,Barbara Secci,Gabriella Collu,Roberta Loddo +13 more
TL;DR: Seven aminoazocompounds and 27 aryltriazene derivatives exhibited antiviral activity, sometimes of high level, against one or more viruses, while a marked activity against BVDV and YFV was prevailing among the former compounds.
Journal ArticleDOI
Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles
Michele Tonelli,Giuseppe Paglietti,Vito Boido,Fabio Sparatore,Fabio Marongiu,Esther Marongiu,Paolo La Colla,Roberta Loddo +7 more
TL;DR: Most compounds exhibited potent activity against RSV, with EC50 values as low as 20 nM, and some compounds, in particular when bearing a (quinolizidin‐1‐yl)alkyl residue, were also moderately active against BVDV, YFV, and CVB2.
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Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease
Bruno Tasso,Marco Catto,Orazio Nicolotti,Federica Novelli,Michele Tonelli,Ilenia Giangreco,Leonardo Pisani,Anna Sparatore,Vito Boido,Angelo Carotti,Fabio Sparatore +10 more
TL;DR: Several quinolizidinyl derivatives of bi- and tricyclic (hetero)aromatic systems were studied as dual, or BChE-selective inhibitors, and may represent hits for the development of interesting single-entity multi-target drugs.
Journal ArticleDOI
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents
Michele Tonelli,Federica Novelli,Bruno Tasso,I. Vazzana,Anna Sparatore,Vito Boido,Fabio Sparatore,Paolo La Colla,Giuseppina Sanna,Gabriele Giliberti,Bernardetta Busonera,Pamela Farci,Cristina Ibba,Roberta Loddo +13 more
TL;DR: A library of eighty-six assorted benzimidazole derivatives was screened for antiviral activity against a panel of ten RNA and DNA viruses and these scaffolds represent valid starting points to develop more efficient agents against pathologies caused by CVB-5, RSV, BVDV and Sb-1 viruses.