P
Paola Posocco
Researcher at University of Trieste
Publications - 114
Citations - 3685
Paola Posocco is an academic researcher from University of Trieste. The author has contributed to research in topics: Dendrimer & Colloidal gold. The author has an hindex of 34, co-authored 111 publications receiving 3271 citations. Previous affiliations of Paola Posocco include Aix-Marseille University & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance
Tuo Wei,Chao Chen,Juan Liu,Cheng Liu,Paola Posocco,Xiaoxuan Liu,Qiang Cheng,Shuaidong Huo,Zicai Liang,Maurizio Fermeglia,Sabrina Pricl,Xing-Jie Liang,Palma Rocchi,Ling Peng +13 more
TL;DR: An innovative drug delivery system based on a self-assembling amphiphilic dendrimer, which can generate supramolecular nanomicelles with large void space in their core to encapsulate anticancer drugs with high loading capacity, was established.
Journal ArticleDOI
Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems.
Xiaoxuan Liu,Jiehua Zhou,Tianzhu Yu,Chao Chen,Qiang Cheng,Kheya Sengupta,Yuanyu Huang,Haitang Li,Cheng Liu,Cheng Liu,Yang Wang,Paola Posocco,Menghua Wang,Menghua Wang,Qi Cui,Suzanne Giorgio,Maurizio Fermeglia,Fanqi Qu,Sabrina Pricl,Yanhong Shi,Zicai Liang,Palma Rocchi,John J. Rossi,Ling Peng +23 more
TL;DR: It is reported for the first time that an amphiphilic dendrimer is able to self-assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors.
Journal ArticleDOI
Degradable self-assembling dendrons for gene delivery: experimental and theoretical insights into the barriers to cellular uptake.
Anna Barnard,Paola Posocco,Sabrina Pricl,Marcelo Calderón,Rainer Haag,Mark E. Hwang,Victor W. T. Shum,Daniel W. Pack,David K. Smith +8 more
TL;DR: It is shown, both experimentally and theoretically, that gene delivery can be correlated with the ability of the dendron assemblies to release DNA, and it is shown that taking this kind of multidisciplinary approach can yield a fundamental insight into the way in which dendrons can navigate barriers to cellular uptake.
Journal ArticleDOI
Sodium montmorillonite silylation: Unexpected effect of the aminosilane chain length
Filomena Piscitelli,Paola Posocco,Radovan Toth,Maurizio Fermeglia,Sabrina Pricl,Giuseppe Mensitieri,Marino Lavorgna +6 more
TL;DR: It was found that the degree of silylation of Na-MMT increases with increasing the length of the aminosilane organic moieties, the overall aminoilane concentration, and temperature, and the same beneficial effects were observed on the silicate d-spacing.
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Polymer-clay nanocomposites: a multiscale molecular modeling approach.
TL;DR: A hierarchical procedure bridging the gap between atomistic and mesoscopic simulation for polymer-clay nanocomposite (PCN) design is presented, and the predicted structure of the nylon 6 PCN system considered is in excellent agreement with previous experimental and atomistic simulation results.