Journal ArticleDOI
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Michele Tonelli,Matteo Simone,Bruno Tasso,Federica Novelli,Vito Boido,Fabio Sparatore,Giuseppe Paglietti,Sabrina Pricl,Gabriele Giliberti,Sylvain Blois,Cristina Ibba,Giuseppina Sanna,Roberta Loddo,Paolo La Colla +13 more
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TLDR
The considered compounds represent attractive leads for the development of antiviral agents against poxviruses, pestiviruses and even HCV, which are important human and veterinary pathogens.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2010-04-15. It has received 145 citations till now.read more
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Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review
Geeta Yadav,Swastika Ganguly +1 more
TL;DR: The present manuscript to the best of the authors' knowledge is the first compilation on synthesis and medicinal aspects including structure-activity relationships of benzimidazole reported to date.
Journal ArticleDOI
Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.
TL;DR: This work systematically gives a comprehensive review in current developments of benzimidazole‐based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti‐inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents.
Journal ArticleDOI
Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors
Yunqi Li,Chunyan Tan,Chunmei Gao,Cunlong Zhang,Xudong Luan,Xiaowu Chen,Hongxia Liu,Yu Zong Chen,Yuyang Jiang +8 more
TL;DR: This study discovered a novel series of benzimidazole derivatives as multi-target EGFR, VEGFR-2 and PDGFR kinases inhibitors, and suggested that compound 5a more tightly interacts with EGFR andPDGFR than compound 5e.
Journal ArticleDOI
Synthesis and characterization of new Cr(III), Fe(III) and Cu(II) complexes incorporating multi-substituted aryl imidazole ligand: Structural, DFT, DNA binding, and biological implications.
Ahmed M. Abu-Dief,Ahmed M. Abu-Dief,Laila H. Abdel-Rahman,Antar A. Abdelhamid,Adel A. Marzouk,Mohamed R. Shehata,Mohamed A. Bakheet,Omar A. Almaghrabi,Ayman Nafady +8 more
TL;DR: Novel Cr(III), Fe(III) and Cu(II) complexes comprising substituted aryl imidazole ligand (MSEB) exhibited powerful antimicrobial activity against various strains of bacteria and fungi and showed high in vitro cytotoxicity against Colon, Breast, and hepatic cellular cell lines.
Journal ArticleDOI
Benzimidazole: a promising pharmacophore
TL;DR: The purpose of this review is to collate the literature work reported by researchers on benzimidazole for its various pharmacological activities and also report recent efforts made on this moiety.
References
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Goodman and Gilman's the Pharmacological Basis of Therapeutics
William H. Stigelman,Pharm D. +1 more
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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
Rudi Pauwels,Jan Balzarini,Masanori Baba,Robert Snoeck,Dominique Schols,Piet Herdewijn,Jan Desmyter,Erik De Clercq +7 more
TL;DR: A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation of anti-HIV agents, which significantly reduced labor time as compared to the trypan blue exclusion method, and permits the evaluation of large numbers of compounds for their anti-hIV activity.
Journal ArticleDOI
An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge
Guang Yang,Daniel C. Pevear,Marc H. Davies,Marc S. Collett,Thomas R. Bailey,Susan Rippen,Barone Linda,Christopher J. Burns,Gerry Rhodes,Sanjeev Tohan,John W. Huggins,Robert O. Baker,R. L. Mark Buller,Erin Touchette,Kem Waller,Jill Schriewer,Johan Neyts,Erik Declercq,Kevin F. Jones,Dennis E. Hruby,Robert Jordan +20 more
TL;DR: Results validate F13L as an antiviral target and demonstrate that an inhibitor of extracellular virus formation can protect mice from orthopoxvirus-induced disease.
Journal ArticleDOI
Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase
Alex William White,Robert Almassy,A. Hilary Calvert,Nicola J. Curtin,Roger J. Griffin,Zdenek Hostomsky,Karen A. Maegley,David R. Newell,S Srinivasan,Bernard T. Golding +9 more
TL;DR: The preclinical development of 2-aryl-1H-benzimidazole-4-carboxamides as resistance-modifying agents in cancer chemotherapy is described, and important hydrogen-bonding and hydrophobic interactions with the protein have been identified for this inhibitor.