M
Michelle Goldsworthy
Researcher at Medical Research Council
Publications - 21
Citations - 952
Michelle Goldsworthy is an academic researcher from Medical Research Council. The author has contributed to research in topics: Mutagenesis (molecular biology technique) & Insulin resistance. The author has an hindex of 12, co-authored 20 publications receiving 843 citations.
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Journal ArticleDOI
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
A. A. Toye,Jonathan D. Lippiat,Peter Proks,Kenju Shimomura,Liz Bentley,Alison Hugill,Vesna Mijat,Michelle Goldsworthy,Lee Moir,A. Haynes,J. Quarterman,Helen Freeman,Frances M. Ashcroft,Roger D. Cox +13 more
TL;DR: The C57BL/6J mouse strain exhibits plasma glucose intolerance reminiscent of human type 2 diabetes, and data suggest a defect in beta cell glucose metabolism that results in reduced electrical activity and insulin secretion.
Journal ArticleDOI
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Paul Potter,Michael R. Bowl,Prashanthini Jeyarajan,Laura Wisby,A Blease,Michelle Goldsworthy,Michelle Simon,Simon Greenaway,Vincent Michel,Alun R. Barnard,Carlos A. Aguilar,Thomas Agnew,Gareth Banks,Andrew Blake,Lauren Chessum,Joanne Dorning,Sara Falcone,Laurence Goosey,Shelley Harris,Andy Haynes,Ines Heise,Rosie Hillier,Tertius Hough,Angela Hoslin,Marie Hutchison,Ruairidh King,Saumya Kumar,Heena V. Lad,Gemma Law,Robert E MacLaren,Susan Morse,T Nicol,Andrew Parker,Karen Pickford,Siddharth Sethi,Becky Starbuck,Femke Stelma,Michael Cheeseman,Sally H. Cross,Russell G. Foster,Ian J. Jackson,Ian J. Jackson,Stuart N. Peirson,Rajesh V. Thakker,Tonia L. Vincent,Cheryl L. Scudamore,Sara Wells,Aziz El-Amraoui,Christine Petit,Abraham Acevedo-Arozena,Patrick M. Nolan,Roger D. Cox,Anne-Marie Mallon,Steve D. M. Brown +53 more
TL;DR: A large-scale genetic screen in mice employing a phenotype-driven discovery platform to identify mutations resulting in age-related disease, both late-onset and progressive, reveals a number of novel pathways involved with age- related disease.
Journal ArticleDOI
Novel phenotypes identified by plasma biochemical screening in the mouse.
Tertius Hough,Patrick M. Nolan,Vicky Tsipouri,A. A. Toye,Ian C. Gray,Michelle Goldsworthy,Lee Moir,Roger D. Cox,Sian Clements,Peter H. Glenister,John Wood,Rachael L. Selley,Mark A. Strivens,Lucie Vizor,Stefan L. McCormack,Josephine Peters,Elizabeth M. C. Fisher,Nigel K. Spurr,Sohaila Rastan,Joanne E. Martin,Steve D.M. Brown,A. Jacqueline Hunter +21 more
TL;DR: The results have validated the biochemical screen, which is applicable to other mutagenesis projects, and a new set of mutants with defined metabolic phenotypes are produced.
Journal ArticleDOI
Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion
Stephan C. Collins,Hyun Woong Do,Benoit Hastoy,Alison Hugill,Julie Adam,Margarita V. Chibalina,Juris Galvanovskis,Mahdieh Godazgar,Sheena Lee,Michelle Goldsworthy,S Albert Salehi,Andrei I. Tarasov,Anders Rosengren,Roger D. Cox,Patrik Rorsman +14 more
TL;DR: Increased SOX4 expression inhibits insulin secretion and increased diabetes risk by the upregulation of STXBP6 and an increase in kiss-and-run exocytosis at the expense of full fusion, and pharmacological interventions promoting fusion pore expansion may be effective in diabetes therapy.
Journal ArticleDOI
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.
Michelle Goldsworthy,Alison Hugill,Helen Freeman,Emma Horner,Kenju Shimomura,Debora Bogani,Guido E Pieles,Vesna Mijat,Ruth M. Arkell,Shoumo Bhattacharya,Frances M. Ashcroft,Roger D. Cox +11 more
TL;DR: IGT4 represents a novel digenic model of insulin resistance coupled with an insulin secretory defect, which exhibits impaired glucose tolerance in association with insulin receptor+/−–induced insulin resistance.