Peter H. Glenister

TL;DR: A genome-wide, phenotype-driven screen for dominant mutations in the mouse is undertaken, which has led to a substantial increase in themouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics.

TL;DR: It is established that a paternally derived targeted deletion of the germline differentially methylated region (DMR) associated with the antisense Nespas transcript unexpectedly affects both the expression of all transcripts in the Gnas cluster and methylation of two DMRs.

TL;DR: The construction of parallel archives of DNA and sperm from mice mutagenized with ENU represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome and the identification of mutations in the gene (Gjb2) encoding connexin 26 is reported.

TL;DR: The X chromosome-linked scurfy (sf) mutant of the mouse is recognized by the scaliness of the skin from which the name is derived and results in death of affected males at about 3-4 weeks of age.

TL;DR: A major ENU mutagenesis program incorporating a large genome-wide screen for dominant mutations and an improved mutant map of the mouse is begun, providing an extensive new resource of mutant and phenotype data to the mouse and human genetics communities at large.