T
Tertius Hough
Researcher at Medical Research Council
Publications - 61
Citations - 3947
Tertius Hough is an academic researcher from Medical Research Council. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 27, co-authored 59 publications receiving 3533 citations. Previous affiliations of Tertius Hough include St James's University Hospital.
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Journal ArticleDOI
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.
Patrick M. Nolan,Josephine Peters,Mark A. Strivens,Derek C. Rogers,Jim J. Hagan,Nigel K. Spurr,Ian C. Gray,Lucie Vizor,D Brooker,E Whitehill,R Washbourne,Tertius Hough,Simon Greenaway,M Hewitt,Xue Zhong Liu,Stefan L. McCormack,K Pickford,R Selley,Christine A. Wells,Zuzanna Tymowska-Lalanne,P. Roby,Peter H. Glenister,C Thornton,Caroline Thaung,J A Stevenson,Ruth M. Arkell,Philomena Mburu,Rachel E. Hardisty,Amy E. Kiernan,Alexandra Erven,Karen P. Steel,Stéphanie Voegeling,Jean-Louis Guénet,Carole D. Nickols,R Sadri,M Nasse,Adrian M. Isaacs,Kay E. Davies,M Browne,Elizabeth M. C. Fisher,Joanne E. Martin,Sohaila Rastan,Steve D.M. Brown,Jackie Hunter +43 more
TL;DR: A genome-wide, phenotype-driven screen for dominant mutations in the mouse is undertaken, which has led to a substantial increase in themouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics.
Journal ArticleDOI
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
Reza M. Salek,Mahon L. Maguire,Elizabeth Bentley,Denis V. Rubtsov,Tertius Hough,Michael Cheeseman,Derek J. Nunez,Brian C. Sweatman,John N. Haselden,Roger D. Cox,Susan C. Connor,Julian L. Griffin +11 more
TL;DR: In this article, 1H-NMR spectra of urine were used in conjunction with uni-and multivariate statistics to identify disease-related metabolic changes in these two animal models and human sufferers.
Journal ArticleDOI
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Michelle Simon,Simon Greenaway,Jacqueline K. White,Helmut Fuchs,Valerie Gailus-Durner,Sara Wells,Tania Sorg,Kim Wong,Elodie Bedu,Elizabeth J. Cartwright,Romain Dacquin,Sophia Djebali,Jeanne Estabel,Jochen Graw,Neil J. Ingham,Ian J. Jackson,Andreas Lengeling,Silvia Mandillo,Jacqueline Marvel,Hamid Meziane,Frédéric Preitner,Oliver Puk,Michel Roux,David J. Adams,Sarah Atkins,Abdel Ayadi,Lore Becker,Andrew Blake,Debra Brooker,Heather Cater,Marie-France Champy,Roy Combe,Petr Danecek,Armida Di Fenza,Hilary Gates,Anna-Karin Gerdin,Elisabetta Golini,John M. Hancock,Wolfgang Hans,Sabine M. Hölter,Tertius Hough,Pierre Jurdic,Thomas M. Keane,Hugh P. Morgan,Werner Müller,Frauke Neff,George Nicholson,Bastian Pasche,Laura-Anne Roberson,Jan Rozman,Mark Sanderson,Luis Santos,Mohammed Selloum,Carl Shannon,Anne Southwell,Glauco P. Tocchini-Valentini,Valerie E. Vancollie,Henrik Westerberg,Wolfgang Wurst,Min Zi,Binnaz Yalcin,Binnaz Yalcin,Ramiro Ramirez-Solis,Karen P. Steel,Ann-Marie Mallon,Martin Hrabě de Angelis,Yann Herault,Steve D.M. Brown +67 more
TL;DR: Comparison of C57BL/6J and C57bl/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains.
Journal ArticleDOI
A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas.
Christine M. Williamson,Simon T. Ball,Wade T. Nottingham,Judith A. Skinner,Antonius Plagge,Martin R Turner,Nicola Powles,Tertius Hough,David Papworth,William D. Fraser,Mark Maconochie,Jo Peters +11 more
TL;DR: It is established that the differentially methylated region at exon 1A contains an imprinting control element that specifically regulates Gnas and comprises a characterized ICR for a gene that is only weakly imprinted in a minority of tissues.
Journal ArticleDOI
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Martin Hrabě de Angelis,George Nicholson,Mohammed Selloum,Jacqueline K. White,Hugh P. Morgan,Ramiro Ramirez-Solis,Tania Sorg,Sara Wells,Helmut Fuchs,Martin Fray,David J. Adams,Niels C. Adams,Thure Adler,Antonio Aguilar-Pimentel,Dalila Ali-Hadji,Gregory Amann,Philippe André,Sarah Atkins,Aurelie Auburtin,Abdel Ayadi,Julien Becker,Lore Becker,Elodie Bedu,Raffi Bekeredjian,Marie-Christine Birling,Andrew Blake,Joanna Bottomley,Michael R. Bowl,Véronique Brault,Dirk H. Busch,James Bussell,Julia Calzada-Wack,Heather Cater,Marie-France Champy,Philippe Charles,Claire Chevalier,Francesco Chiani,Gemma F. Codner,Roy Combe,Roger D. Cox,Emilie Dalloneau,André Dierich,Armida Di Fenza,Brendan Doe,Arnaud Duchon,Oliver Eickelberg,Christopher T. Esapa,Lahcen El Fertak,Tanja Feigel,Irina Emelyanova,Jeanne Estabel,Jack Favor,Ann M Flenniken,Alessia Gambadoro,Lilian Garrett,Hilary Gates,Anna-Karin Gerdin,George Gkoutos,Simon Greenaway,Lisa Glasl,Patrice Goetz,Isabelle Goncalves Da Cruz,Alexander Götz,Jochen Graw,Alain Guimond,Wolfgang Hans,Geoff Hicks,Sabine M. Hölter,Heinz Höfler,John M. Hancock,Robert Hoehndorf,Tertius Hough,Richard Houghton,Anja Hurt,Boris Ivandic,Hughes Jacobs,Sylvie Jacquot,Nora Jones,Natasha A. Karp,Hugo A. Katus,Sharon Kitchen,Tanja Klein-Rodewald,Martin Klingenspor,Thomas Klopstock,Valérie Lalanne,Sophie Leblanc,Christoph Lengger,Elise le Marchand,Tonia Ludwig,Aline Lux,Colin McKerlie,Holger Maier,Jean-Louis Mandel,Susan Marschall,Manuel Mark,David Melvin,Hamid Meziane,Kateryna Micklich,Christophe Mittelhauser,Laurent Monassier,David Moulaert,Stéphanie Muller,Beatrix Naton,Frauke Neff,Patrick M. Nolan,Lauryl M. J. Nutter,Markus Ollert,Guillaume Pavlovic,Natalia S. Pellegata,Emilie Peter,Benoit Petit-Demoulière,Amanda R. Pickard,Christine Podrini,Paul Potter,Laurent Pouilly,Oliver Puk,David S. Richardson,Stephane Rousseau,Leticia Quintanilla-Fend,Mohamed M. Quwailid,Ildiko Racz,Birgit Rathkolb,Fabrice Riet,Janet Rossant,Michel Roux,Jan Rozman,Edward Ryder,Jennifer Salisbury,Luis Santos,Karl-Heinz Schäble,Evelyn Schiller,Anja Schrewe,Holger Schulz,Ralf Steinkamp,Michelle Simon,Michelle Stewart,Claudia Stöger,Tobias Stöger,Minxuan Sun,David Sunter,Lydia Teboul,Isabelle Tilly,Glauco P. Tocchini-Valentini,Monica Tost,Irina Treise,Laurent Vasseur,Emilie Velot,Daniela Vogt-Weisenhorn,Christelle Wagner,Alison Walling,Marie Wattenhofer-Donzé,Bruno Weber,Olivia Wendling,Henrik Westerberg,Monja Willershäuser,Eckhard Wolf,Anne Wolter,Joe Wood,Wolfgang Wurst,Ali Önder Yildirim,Ramona Zeh,Andreas Zimmer,Annemarie Zimprich,Christopher Holmes,Karen P. Steel,Yann Herault,Valerie Gailus-Durner,Ann-Marie Mallon,Steve D.M. Brown +168 more
TL;DR: New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.