Michelle L. Swearingen

TL;DR: The results strongly suggest that VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types.

TL;DR: These findings demonstrate that it is possible to utilize longitudinal samples from an in vivo model of colon carcinoma to identify genes up-regulated in metastases and that HES-6 may be an important marker of a range of primary cancers as well as metastatic Colon carcinoma.

TL;DR: It is suggested that somatic mutations in CCK2R may promote tumorigenesis through deregulated receptor activity and highlight the importance of evaluating CCK 2R inhibitors to block both the normal and mutant forms of the receptor.

TL;DR: The in vitro approach is used to develop an in vivo co-implant vasculogenesis model that connects with the endogenous vasculature to form functional blood vessels that become insensitive to VEGF inhibition over time.

TL;DR: It is found that cord formation driven by different angiogenic factors led to unique phenotypes that could be differentiated and combination studies indicate dominant phenotypes elicited by some growth factors, which may lead to improvements in therapeutic angiogenesis efforts and better rational for anti-angiogenic therapy.