D
David W. Griggs
Researcher at Saint Louis University
Publications - 64
Citations - 3530
David W. Griggs is an academic researcher from Saint Louis University. The author has contributed to research in topics: Integrin & Fibrosis. The author has an hindex of 21, co-authored 60 publications receiving 3017 citations. Previous affiliations of David W. Griggs include Pfizer & Washington University in St. Louis.
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Journal ArticleDOI
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
Neil C. Henderson,Thomas D. Arnold,Yoshio Katamura,Marilyn M. Giacomini,Juan D Rodriguez,Joseph H. McCarty,Antonella Pellicoro,Elisabeth Raschperger,Elisabeth Raschperger,Christer Betsholtz,Christer Betsholtz,Peter G. Ruminski,David W. Griggs,Michael J. Prinsen,Jacquelyn J. Maher,John P. Iredale,Adam Lacy-Hulbert,Ralf H. Adams,Dean Sheppard +18 more
TL;DR: Pdgfrb-Cre effectively targeted myofibroblasts in multiple organs, and depletion of the αv integrin subunit using this system was protective in other models of organ fibrosis, including pulmonary and renal fibrosis.
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Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.
Ruo-Hua Song,Micky D. Tortorella,Anne-Marie Malfait,James T. Alston,Zhiyong Yang,Elizabeth C. Arner,David W. Griggs +6 more
TL;DR: Despite the apparent dominant role of ADAMTS-5 in genetically modified mice, the data suggest that both ADAMts-4 and ADAM TS-5 contribute to the structural damage that characterizes human OA.
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A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.
V W Engleman,G A Nickols,F. P. Ross,Michael A. Horton,David W. Griggs,Steven L. Settle,Peter G. Ruminski,Steven L. Teitelbaum +7 more
TL;DR: A synthetic chemical peptide mimetic based upon the alpha(v)beta3 ligand, Arg-Gly-Asp (RGD), which recognizes the isolated integrin, and its relative, alpha( v)beta5, as effectively as does the natural peptide, dampens osteoclastic bone resorption in vitro and in vivo.
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Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
Amir Abdollahi,David W. Griggs,Heike Zieher,Alexandra Roth,Kenneth E. Lipson,Rainer Saffrich,Hermann Josef Gröne,Dennis E. Hallahan,Ralph A. Reisfeld,Juergen Debus,Andreas G. Niethammer,Peter E. Huber +11 more
TL;DR: It is shown that combined treatment with S247, an Arg-Gly-Glu peptidomimetic antagonist of αvβ3 integrin, and external beam radiotherapy are beneficial in local tumor therapy and that the combination of integrin antagonists and radiotherapy represents a rational approach in local cancer therapy.
Journal ArticleDOI
Regulated expression of the GAL4 activator gene in yeast provides a sensitive genetic switch for glucose repression
David W. Griggs,Mark Johnston +1 more
TL;DR: The results suggest that GAL4 works synergistically to activate GAL1 expression, illustrating how modest regulation of a weakly expressed regulatory gene can act as a sensitive genetic switch to produce greatly amplified responses to environmental changes.