M
Mikko Karjalainen
Researcher at University of Jyväskylä
Publications - 8
Citations - 396
Mikko Karjalainen is an academic researcher from University of Jyväskylä. The author has contributed to research in topics: Integrin & Endosome. The author has an hindex of 7, co-authored 8 publications receiving 373 citations.
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Journal ArticleDOI
BioImageXD: an open, general-purpose and high-throughput image-processing platform
Pasi Kankaanpää,Lassi Paavolainen,Silja Tiitta,Mikko Karjalainen,Joacim Päivärinne,Jonna Nieminen,Varpu Marjomäki,Jyrki Heino,Daniel J. White +8 more
TL;DR: BioImageXD allows simple construction of processing pipelines and should enable biologists to perform challenging analyses of complex processes, and is demonstrated in a study of integrin clustering in response to selected inhibitors.
Journal ArticleDOI
A Raft-derived, Pak1-regulated Entry Participates in α2β1 Integrin-dependent Sorting to Caveosomes
Mikko Karjalainen,Elina Kakkonen,Paula Upla,Heli Paloranta,Pasi Kankaanpää,Prisca Liberali,G. Herma Renkema,Timo Hyypiä,Jyrki Heino,Varpu Marjomäki +9 more
TL;DR: The results together suggest that alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes.
Journal ArticleDOI
Echovirus 1 infection depends on biogenesis of novel multivesicular bodies
Mikko Karjalainen,Nina Rintanen,Moona Lehkonen,Katri Kallio,Anita Mäki,Kirsi Hellström,Valtteri Siljamäki,Paula Upla,Varpu Marjomäki +8 more
TL;DR: The results show that the non‐enveloped EV1 depends on biogenesis of novel multivesicular structures for successful infection and the involvement of ESCRTs in theBiogenesis of α2‐MVBs is demonstrated.
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Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway
Nina Rintanen,Mikko Karjalainen,Jonna Alanko,Lassi Paavolainen,Anita Mäki,Liisa Nissinen,Moona Lehkonen,Katri Kallio,R. Holland Cheng,Paula Upla,Johanna Ivaska,Johanna Ivaska,Varpu Marjomäki +12 more
TL;DR: A novel virus- and integrin clustering–specific pathway diverts integrin from its normal endo/exocytic traffic to a nonrecycling degradative endosomal route, leading to enhanced integrin turnover promoted by calpains.
Journal ArticleDOI
Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.
Elina Siljamäki,Nina Rintanen,Maija Kirsi,Paula Upla,Wei Wang,Wei Wang,Mikko Karjalainen,Elina Ikonen,Elina Ikonen,Varpu Marjomäki +9 more
TL;DR: The results showed that the integrin internalization pathway is dependent on cholesterol for uptake of collagen, EV1 and integrin, for maturation of endosomal structures and for promoting EV1 uncoating.