M
Min-Kyu Cho
Researcher at New York University
Publications - 30
Citations - 1112
Min-Kyu Cho is an academic researcher from New York University. The author has contributed to research in topics: Protein structure & Nuclear magnetic resonance spectroscopy. The author has an hindex of 17, co-authored 29 publications receiving 981 citations. Previous affiliations of Min-Kyu Cho include Novartis & Vanderbilt University Medical Center.
Papers
More filters
Journal ArticleDOI
Structural Properties of Pore-Forming Oligomers of α-Synuclein
Hai-Young Kim,Min-Kyu Cho,Ashutosh Kumar,Elke Maier,Carsten Siebenhaar,Stefan Becker,Claudio O. Fernández,Hilal A. Lashuel,Roland Benz,Adam Lange,Markus Zweckstetter +10 more
TL;DR: On-pathway oligomers of the 140-residue protein alpha-synuclein, a key player in Parkinson's disease, are prepared at concentrations an order of magnitude higher than previously possible.
Journal ArticleDOI
Structural characterization of α-synuclein in an aggregation prone state.
Min-Kyu Cho,Gabrielle Nodet,Hai-Young Kim,Malene Ringkjøbing Jensen,Pau Bernadó,Claudio O. Fernández,Stefan Becker,Martin Blackledge,Markus Zweckstetter +8 more
TL;DR: NMR demonstrated that αS remains natively unfolded at lower pH, but secondary structure propensities were changed in proximity to acidic residues, and the ensemble of conformations of αS at acidic pH is characterized by a rigidification and compaction of the Asp and Glu‐rich C‐terminal region.
Journal ArticleDOI
Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin
Tiandi Zhuang,Qiuyan Chen,Min-Kyu Cho,Sergey A. Vishnivetskiy,Tina M. Iverson,Vsevolod V. Gurevich,Charles R. Sanders +6 more
TL;DR: It is hypothesized that complex formation with either P-Rh* or P-opsin results in a global transition in the conformation of arrestin-1, possibly to a dynamic molten globule-like structure, and contributes to the mechanism that triggers preferential interactions of several signaling proteins with receptor-activated arrestins.
Journal ArticleDOI
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action
Hajer Ouertatani-Sakouhi,Farah El-Turk,Bruno Fauvet,Min-Kyu Cho,Damla Pinar Karpinar,Didier Le Roy,Manfred Dewor,Thierry Roger,Jürgen Bernhagen,Thierry Calandra,Markus Zweckstetter,Hilal A. Lashuel +11 more
TL;DR: All inhibitors demonstrated total inhibition of MIF-mediated glucocorticoid overriding and AKT phosphorylation, whereas ebselen, a trimer-disrupting inhibitor, additionally acted as a potent hyperagonist in Mif-mediated chemotactic migration.
Journal ArticleDOI
Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
Ralf Jauch,Ralf Jauch,Min-Kyu Cho,Stefan Jäkel,Catharina Netter,Kay Schreiter,Babette Aicher,Markus Zweckstetter,Herbert Jäckle,Markus C. Wahl +9 more
TL;DR: Structural rearrangements required for the activation of Mnks are apparent from the cocrystal structure of a Mnk2D228G–staurosporine complex and can be modeled on the basis of crystal packing interactions and suggest a novel regulatory mechanism specific for the Mnk subfamily.