M
Markus C. Wahl
Researcher at Free University of Berlin
Publications - 187
Citations - 10804
Markus C. Wahl is an academic researcher from Free University of Berlin. The author has contributed to research in topics: RNA & Spliceosome. The author has an hindex of 48, co-authored 169 publications receiving 9698 citations. Previous affiliations of Markus C. Wahl include Boehringer Ingelheim & University of Göttingen.
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Journal ArticleDOI
The Spliceosome: Design Principles of a Dynamic RNP Machine
TL;DR: The spliceosome exhibits exceptional compositional and structural dynamics that are exploited during substrate-dependent complex assembly, catalytic activation, and active site remodeling in the pre-mRNAs.
Journal ArticleDOI
Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation
Mihaela Diaconu,Ute Kothe,Frank Schlünzen,Niels Fischer,J. Harms,Alexander G. Tonevitsky,Holger Stark,Marina V. Rodnina,Markus C. Wahl +8 more
TL;DR: In this paper, the L7/12 stalk of the large subunit of bacterial ribosomes is organized into three elements (stalk base, L10 helix α8-L7/ 12 N-terminal-domain complex, and L 7/12 Cterminal domains) linked by flexible connections.
Journal ArticleDOI
Helical extension of the neuronal SNARE complex into the membrane.
TL;DR: The results suggest that the final phase of SNARE assembly is directly coupled to membrane merger, and this structure shows that assembly proceeds beyond the already known core SNARE complex, resulting in a continuous helical bundle that is further stabilized by side-chain interactions in the linker region.
Journal ArticleDOI
C-h...o hydrogen bonding in biology
TL;DR: Observations of short CH…O contacts in biological macromolecules, including nucleic acids, proteins and carbohydrates, suggest that these unconventional hydrogen bonds have both a structurally and functionally important role.
Journal ArticleDOI
A NusE:NusG Complex Links Transcription and Translation
Björn M. Burmann,Kristian Schweimer,Xiao Luo,Markus C. Wahl,Barbara L. Stitt,Max E. Gottesman,Paul Rösch +6 more
TL;DR: Un Uncoupling of transcription and translation at the ends of bacterial operons enables transcription termination by Rho factor, and competition between ribosomal NusE and Rho for NusG helps to explain why Rho cannot terminate translated transcripts.