M
Manfred Dewor
Researcher at RWTH Aachen University
Publications - 15
Citations - 1890
Manfred Dewor is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Chemokine receptor. The author has an hindex of 11, co-authored 15 publications receiving 1713 citations.
Papers
More filters
Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TL;DR: Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
Journal ArticleDOI
A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells.
Rüdiger Blindt,Felix Vogt,Irina Astafieva,Christian Fach,Mihail Hristov,Nicole Krott,Berthold Seitz,Aphrodite Kapurniotu,Connie Kwok,Manfred Dewor,Anja-Katrin Bosserhoff,Jürgen Bernhagen,Peter Hanrath,Rainer Hoffmann,Christian Weber +14 more
TL;DR: Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs).
Journal ArticleDOI
Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74.
TL;DR: Together, these data show that the CXCR4/CD74/SRC/PI3K axis mediates a rapid and transient activation of the JNK pathway as triggered by the inflammatory cytokine MIF in T cells and fibroblasts.
Journal ArticleDOI
Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase.
TL;DR: Ostermeier et al. as discussed by the authors presented evidence from four distantly related cytochrome-c oxidases for the existence of a copperB-coordinated His240-Tyr244 crosslink at the O2-activating Heme Fea3-CuB center in the catalytic subunit 1 of the enzyme.
Journal ArticleDOI
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action
Hajer Ouertatani-Sakouhi,Farah El-Turk,Bruno Fauvet,Min-Kyu Cho,Damla Pinar Karpinar,Didier Le Roy,Manfred Dewor,Thierry Roger,Jürgen Bernhagen,Thierry Calandra,Markus Zweckstetter,Hilal A. Lashuel +11 more
TL;DR: All inhibitors demonstrated total inhibition of MIF-mediated glucocorticoid overriding and AKT phosphorylation, whereas ebselen, a trimer-disrupting inhibitor, additionally acted as a potent hyperagonist in Mif-mediated chemotactic migration.