M
Mine Koruyucu
Researcher at Istanbul University
Publications - 80
Citations - 1181
Mine Koruyucu is an academic researcher from Istanbul University. The author has contributed to research in topics: Amelogenesis imperfecta & Medicine. The author has an hindex of 15, co-authored 64 publications receiving 872 citations. Previous affiliations of Mine Koruyucu include Istanbul Medipol University.
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Journal ArticleDOI
A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13
Elizabeth J. Leslie,Jenna C. Carlson,John R. Shaffer,Eleanor Feingold,George L. Wehby,Cecelia A. Laurie,Deepti Jain,Cathy C. Laurie,Kimberly F. Doheny,Toby Goldstein McHenry,Judith M. Resick,Carla A. Sanchez,Jennifer Jacobs,Beth Emanuele,Alexandre R. Vieira,Katherine Neiswanger,Andrew C. Lidral,Luz Consuelo Valencia-Ramirez,Ana Maria Lopez-Palacio,Dora Rivera Valencia,Mauricio Arcos-Burgos,Andrew E. Czeizel,L. Leigh Field,Carmencita Padilla,Eva Maria Cutiongco-de la Paz,Frederic W.-B. Deleyiannis,Kaare Christensen,Ronald G. Munger,Rolv T. Lie,Allen J. Wilcox,Paul A. Romitti,Eduardo E. Castilla,Juan C. Mereb,Fernando A. Poletta,Iêda M. Orioli,Flávia Martinez de Carvalho,Jacqueline T. Hecht,Susan H. Blanton,Carmen J. Buxó,Azeez Butali,Peter A. Mossey,Wasiu Lanre Adeyemo,Olutayo James,Ramat Oyebunmi Braimah,Babatunde S. Aregbesola,Mekonen Eshete,Fikre Abate,Mine Koruyucu,Figen Seymen,Lian Ma,Javier Enríquez de Salamanca,Seth M. Weinberg,Lina M. Moreno,Jeffrey C. Murray,Mary L. Marazita +54 more
TL;DR: A multiethnic genome-wide association study with European, Asian, African and Central and South American ancestry revealed novel CL/P risk loci and suggest new genes involved in craniofacial development, confirming the highly heterogeneous etiology of OFCs.
Journal ArticleDOI
Genes expressed in dental enamel development are associated with molar-incisor hypomineralization
Fabiano Jeremias,Mine Koruyucu,Erika Calvano Küchler,Merve Bayram,Elif Bahar Tuna,Kathleen Deeley,Ricardo Augusto Gonçalves Pierri,Juliana Feltrin de Souza,Camila Maria Bullio Fragelli,Marco Aurélio Benini Paschoal,Koray Gençay,Figen Seymen,Raquel Mantuaneli Scarel Caminaga,Lourdes Aparecida Martins dos Santos-Pinto,Alexandre R. Vieira +14 more
TL;DR: Several genes involved in enamel formation appear to contribute to molar-incisor hypomineralization (MIH), and allele and genotype frequencies between cases with MIH and controls were compared.
Journal ArticleDOI
A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3
Elizabeth J. Leslie,Huan Liu,Huan Liu,Jenna C. Carlson,John R. Shaffer,Eleanor Feingold,George L. Wehby,Cecelia A. Laurie,Deepti Jain,Cathy C. Laurie,Kimberly F. Doheny,Toby Goldstein McHenry,Judith M. Resick,Carla A. Sanchez,Jennifer Jacobs,Beth Emanuele,Alexandre R. Vieira,Katherine Neiswanger,Jennifer Standley,Andrew E. Czeizel,Frederic W.-B. Deleyiannis,Kaare Christensen,Ronald G. Munger,Rolv T. Lie,Allen J. Wilcox,Paul A. Romitti,L. Leigh Field,Carmencita Padilla,Eva Maria Cutiongco-de la Paz,Eva Maria Cutiongco-de la Paz,Andrew C. Lidral,Luz Consuelo Valencia-Ramirez,Ana Maria Lopez-Palacio,Dora Rivera Valencia,Mauricio Arcos-Burgos,Eduardo E. Castilla,Juan C. Mereb,Fernando A. Poletta,Iêda M. Orioli,Flávia Martinez de Carvalho,Jacqueline T. Hecht,Susan H. Blanton,Carmen J. Buxó,Azeez Butali,Peter A. Mossey,Wasiu Lanre Adeyemo,Olutayo James,Ramat Oyebunmi Braimah,Babatunde S. Aregbesola,Mekonen Eshete,Milliard Deribew,Mine Koruyucu,Figen Seymen,Lian Ma,Javier Enríquez de Salamanca,Seth M. Weinberg,Lina M. Moreno,Robert A. Cornell,Jeffrey C. Murray,Mary L. Marazita +59 more
TL;DR: A genome-wide significant association with a missense variant in GRHL3 is discovered and it is concluded that this mutation is an etiologic variant for nonsyndromic CP and is one of few functional variants identified to date for nonsYNDromic orofacial clefting.
Journal ArticleDOI
Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta.
David A. Parry,David A. Parry,Claire E. L. Smith,Walid El-Sayed,James A. Poulter,R.C. Shore,Clare V. Logan,Chihiro Mogi,Koichi Sato,Fumikazu Okajima,Akihiro Harada,Hong Zhang,Mine Koruyucu,Figen Seymen,Jan C.-C. Hu,James P. Simmer,Mushtaq Ahmed,Hussain Jafri,Colin A. Johnson,Chris F. Inglehearn,Alan J. Mighell +20 more
TL;DR: Immunohistochemistry of rat mandibles confirmed localization of GPR68 in the enamel organ at all stages of amelogenesis, identifying a role for GPR 68 as a proton sensor that is required for proper enamel formation.
Journal ArticleDOI
Mutations in RELT cause autosomal recessive amelogenesis imperfecta
Jung-Wook Kim,Hong Zhang,Figen Seymen,Mine Koruyucu,Yuanyuan Hu,Jenny Kang,Youn Jung Kim,Atsushi Ikeda,Yelda Kasimoglu,Merve Bayram,Chuhua Zhang,Kazuhiko Kawasaki,John D. Bartlett,Thomas L. Saunders,James P. Simmer,Jan C.-C. Hu +15 more
TL;DR: Phylogenetic analyses showed the existence of selective pressure on RELT gene outside of tooth development, indicating that the human condition may be syndromic, which possibly explains the history of small stature and severe childhood infections in two of the probands.