S
Sherry Niessen
Researcher at Pfizer
Publications - 89
Citations - 7841
Sherry Niessen is an academic researcher from Pfizer. The author has contributed to research in topics: Signal transduction & Serine hydrolase. The author has an hindex of 44, co-authored 83 publications receiving 6990 citations. Previous affiliations of Sherry Niessen include Scripps Research Institute & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
Daniel K. Nomura,Jonathan Z. Long,Sherry Niessen,Heather Hoover,Shu-Wing Ng,Benjamin F. Cravatt +5 more
TL;DR: Overexpression of MAGL in nonaggressive cancer cells recapitulates this fatty acid network and increases their pathogenicity-phenotypes that are reversed by an MAGL inhibitor, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity.
Journal ArticleDOI
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
Robert A. Screaton,Michael D. Conkright,Yoshiko Katoh,Jennifer L. Best,Gianluca Canettieri,Shawn Jeffries,Ernesto Guzman,Sherry Niessen,John R. Yates,Hiroshi Takemori,Mitsuhiro Okamoto,Marc Montminy +11 more
TL;DR: A signaling module that mediates the synergistic effects of these pathways on cellular gene expression by stimulating the dephosphorylation and nuclear entry of TORC2, a CREB coactivator, consists of the calcium-regulated phosphatase calcineurin and the Ser/Thr kinase SIK2, both of which associate withTORC2.
Journal ArticleDOI
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension
Iain M. Cheeseman,Sherry Niessen,Scott Anderson,Francie Hyndman,John R. Yates,Karen Oegema,Arshad Desai +6 more
TL;DR: A set of 10 copurifying kinetochore proteins from Caenorhabditis elegans are identified, seven of which were previously uncharacterized, and it is shown that thisCopurifying protein network plays a central role at the kinetchore-microtubule interface.
Journal ArticleDOI
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
Bryan R. Lanning,Landon R. Whitby,Melissa M. Dix,John Douhan,Adam M. Gilbert,Erik C. Hett,Theodore O. Johnson,Chris Joslyn,John Charles Kath,Sherry Niessen,Lee R. Roberts,Mark E. Schnute,Chu Wang,Jonathan J. Hulce,Baoxian Wei,Laurence O. Whiteley,Matthew Merrill Hayward,Benjamin F. Cravatt +17 more
TL;DR: This work uses activity-based protein profiling coupled with quantitative mass spectrometry to globally map the targets, both specific and non-specific, of covalent kinase inhibitors in human cells and shows that, when these windows are exceeded, rampant proteome-wide reactivity and kinase target-independent cell death conjointly occur.
Journal ArticleDOI
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
Ling Qi,Jose E. Heredia,Judith Y. Altarejos,Robert A. Screaton,Naomi Goebel,Sherry Niessen,Ian MacLeod,Chong Wee Liew,Rohit N. Kulkarni,James R. Bain,Christopher B. Newgard,Michael C. Nelson,Ronald M. Evans,John R. Yates,Marc Montminy +14 more
TL;DR: Because transgenic mice expressing TRB3 in adipose tissue are protected from diet-induced obesity due to enhanced fatty acid oxidation, these results demonstrate how phosphorylation and ubiquitination pathways converge on a key regulator of lipid metabolism to maintain energy homeostasis.