Minglin Lang

TL;DR: It is shown that zinc contributes to the development of Tau toxicity through two independent actions: by increasing Tau phosphorylation and, more significantly, by directly binding to Tau through amino acid substitution of Cys residues.

TL;DR: Evidence is presented that Drosophila melanogaster multicopper oxidase-1 (MCO1) is a functional ferroxidase and that MCO1 oxidizes ferrous iron in the hemolymph and that the resulting ferric iron is bound by transferrin or melanotransferrin, leading to iron storage, iron withholding from pathogens, regulation of oxidative stress, and/or epithelial maturation.

TL;DR: A better understanding of Cu ions’ current status in several AD features is presented, and a short review of the modern therapeutic approach in chelation therapy, with the main focus on Cu ions is discussed.

TL;DR: The present transgenic Drosophila system potentially showed that a quantitative increase in carboxylesterases induced broader resistance of insects to insecticides than a qualitative change.

TL;DR: It is suggested that zinc contributes significantly to the Aβ pathology, and manipulation of zinc transporters in AD brains may provide a novel therapeutic strategy.