M
Mingyue Zheng
Researcher at Chinese Academy of Sciences
Publications - 273
Citations - 5783
Mingyue Zheng is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 34, co-authored 215 publications receiving 3867 citations. Previous affiliations of Mingyue Zheng include Ocean University of China & Southern Medical University.
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Journal ArticleDOI
Estimation of elimination half-lives of organic chemicals in humans using gradient boosting machine.
Jing Lu,Dong Lu,Dong Lu,Xiaochen Zhang,Yi Bi,Keguang Cheng,Mingyue Zheng,Xiaomin Luo,Xiaomin Luo +8 more
TL;DR: It is expected that the GBM model for elimination half-life would have potential applications for the early pharmacokinetic evaluations, and provide guidance for designing drug candidates with favorable in vivo exposure profile.
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Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy
Jing Gao,Bo Hou,Qiwen Zhu,Lei Yang,Xingyu Jiang,Zhifeng Zou,Xutong Li,Tianfeng Xu,Mingyue Zheng,Yi-Hung Chen,Zhiai Xu,Hui-Xiong Xu,Haijun Yu +12 more
TL;DR: In this paper , a de novo designed polymeric PROTAC (POLY-PROTAC) nanotherapeutics for tumour-specific protein degradation is presented, which self-assemble into micellar nanoparticles and sequentially respond to extracellular matrix metalloproteinase-2, intracellular acidic and reductive tumour microenvironment.
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Applying high-performance computing in drug discovery and molecular simulation
Ting-ting Liu,Dong Lu,Hao Zhang,Mingyue Zheng,Huaiyu Yang,Yechun Xu,Cheng Luo,Weiliang Zhu,Kunqian Yu,Hualiang Jiang +9 more
TL;DR: This review mainly focuses on the application of HPC to the fields of drug discovery and molecular simulation at the Chinese Academy of Sciences, including virtual drug screening, molecular dynamics simulation, and protein folding.
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Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation.
Yan Wang,Zunyun Fu,Xutong Li,Yinming Liang,Siyu Pei,Shumeng Hao,Qingchen Zhu,Tao Yu,Yifei Pei,Jia Yuan,Jialin Ye,Jiemeng Fu,Jing Xu,Jin Hong,Ruirui Yang,Hui Hou,Xinfang Huang,Chao Peng,Mingyue Zheng,Yichuan Xiao +19 more
TL;DR: In this paper, the KU complex was found abundantly expressed in the cytoplasm, where it recognized accumulated cyTOPlasmic DNA in aged human and mouse CD4+ T-cells.
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In silico site of metabolism prediction for human UGT-catalyzed reactions.
Jianlong Peng,Jing Lu,Qiancheng Shen,Mingyue Zheng,Xiaomin Luo,Weiliang Zhu,Hualiang Jiang,Kaixian Chen +7 more
TL;DR: Four in silico models to predict sites of glucuronidation, for four major sites of metabolism functional groups, i.e. aliphatic hydroxyl, aromatic hydroxym, carboxylic acid or amino nitrogen, respectively are developed.