M
Mireille Desille
Researcher at University of Rennes
Publications - 10
Citations - 348
Mireille Desille is an academic researcher from University of Rennes. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 9, co-authored 10 publications receiving 325 citations.
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Journal ArticleDOI
DNAX accessory molecule‐1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vγ9Vδ2 T cells
Olivier Toutirais,Florian Cabillic,Gaelle Le Friec,Samuel Salot,Pascal Loyer,Matthieu Le Gallo,Mireille Desille,Cécile Thomas de La Pintière,Pascale Daniel,Françoise Bouet,Véronique Catros +10 more
TL;DR: This study showed that the two NK receptors DNAX accessory molecule‐1 (DNAM‐1) and CD96 were expressed by Vγ9Vδ2 T cells and demonstrated by mAb‐mediated masking experiments that cytotoxicity against HCC cells as well as IFN‐γ production in γδ T cells were dependent on DNAM‐ 1.
Journal ArticleDOI
Hypothermic Storage and Cryopreservation of Hepatocytes: The Protective Effect of Alginate Gel against Cell Damages:
Stephan Mahler,Mireille Desille,Benjamin Frémond,Christophe Chesne,André Guillouzo,Jean-Pierre Campion,Bruno Clément +6 more
TL;DR: Cold-induced apoptosis in hepatocytes can be significantly reduced following their entrapment within alginate gel beads and this is associated with an improvement of both their viability and function.
Journal ArticleDOI
Detoxifying activity in pig livers and hepatocytes intended for xenotherapy
Mireille Desille,Laurent Corcos,Annie L'Helgoualc'h,Benjamin Fremond,Jean-Pierre Campion,André Guillouzo,Bruno Clément +6 more
TL;DR: Porcine livers and hepatocytes from pigs can detoxify a large spectrum of exogenous and endogenous compounds, which makes them a convenient substitute for allogeneic transplants for patients with liver failure.
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HLA-A*0201-restricted CEA-derived peptide CAP1 is not a suitable target for T-cell-based immunotherapy.
Emilie Fauquembergue,Olivier Toutirais,David Tougeron,Aurélie Drouet,Matthieu Le Gallo,Mireille Desille,Florian Cabillic,Cécile Thomas de La Pintière,Manuela Iero,Licia Rivoltini,Stéphanie Baert-Desurmont,Jérôme Leprince,Hubert Vaudry,Richard Sesboüé,Thierry Frebourg,Jean Baptiste Latouche,Véronique Catros +16 more
TL;DR: The data indicate that CAP1 is not efficiently processed and presented by CEA+ tumor cells, and therefore, is not an appropriate target for T-cell-based immunotherapy.
Journal ArticleDOI
Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma.
Laurent Sulpice,Mireille Desille,Bruno Turlin,Alain Fautrel,Karim Boudjema,Bruno Clément,Cédric Coulouarn +6 more
TL;DR: The genomic dataset provides insights on the molecular pathways altered in the microenvironment of ICC and allows the identification of novel ICC biomarkers, as exemplified previously in Hepatology.