M
Miriam Casiraghi
Researcher at Vita-Salute San Raffaele University
Publications - 17
Citations - 2645
Miriam Casiraghi is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Hematopoietic stem cell transplantation & Genetic enhancement. The author has an hindex of 11, co-authored 14 publications receiving 2276 citations.
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Journal ArticleDOI
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.
Alessandra Biffi,Eugenio Montini,Laura Lorioli,Martina Cesani,Francesca Fumagalli,Tiziana Plati,Cristina Baldoli,Sabata Martino,Andrea Calabria,Sabrina Canale,Fabrizio Benedicenti,Giuliana Vallanti,Luca Biasco,Simone Leo,Nabil Kabbara,Gianluigi Zanetti,William B. Rizzo,Nalini Mehta,Maria Pia Cicalese,Miriam Casiraghi,Jaap Jan Boelens,Ubaldo Del Carro,David J. Dow,Manfred Schmidt,Andrea Assanelli,Victor Neduva,Clelia Di Serio,Elia Stupka,Jason P. Gardner,Christof von Kalle,Claudio Bordignon,Claudio Bordignon,Fabio Ciceri,Attilio Rovelli,Maria Grazia Roncarolo,Alessandro Aiuti,Maria Sessa,Luigi Naldini +37 more
TL;DR: The reconstitution of ARSA activity in the cerebrospinal fluid and the arrested progression of neurodegenerative disease in the three treated patients demonstrate that the transplanted cells, or their progeny, can seed the nervous system and deliver therapeutic levels of active enzyme.
Journal ArticleDOI
Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome
Alessandro Aiuti,Luca Biasco,Samantha Scaramuzza,Francesca Ferrua,Maria Pia Cicalese,Cristina Baricordi,Francesca Dionisio,Andrea Calabria,Stefania Giannelli,Maria Carmina Castiello,Marita Bosticardo,Costanza Evangelio,Andrea Assanelli,Miriam Casiraghi,Sara Di Nunzio,Luciano Callegaro,Claudia Benati,Paolo Rizzardi,Danilo Pellin,Clelia Di Serio,Manfred G. Schmidt,Christof von Kalle,Jason P. Gardner,Nalini Mehta,Victor Neduva,David J. Dow,Anne Galy,Roberto Miniero,Andrea Finocchi,Ayse Metin,Pinaki P. Banerjee,Jordan S. Orange,Stefania Galimberti,Maria Grazia Valsecchi,Alessandra Biffi,Eugenio Montini,Anna Villa,Fabio Ciceri,Maria Grazia Roncarolo,Luigi Naldini +39 more
TL;DR: A clinical protocol based on lentiviral vector (LV) gene transfer into autologous hematopoietic stem/progenitor cells (HSCs) resulted in robust, stable, and long-term engraftment of gene-corrected HSCs in the patients’ bone marrow, and the findings support the use of LV gene therapy to treat patients with WAS.
Journal ArticleDOI
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency
Maria Pia Cicalese,Francesca Ferrua,Laura Castagnaro,Roberta Pajno,Federica Barzaghi,Stefania Giannelli,Francesca Dionisio,Immacolata Brigida,Marco Bonopane,Miriam Casiraghi,Antonella Tabucchi,Filippo Carlucci,Eyal Grunebaum,Mehdi Adeli,Robbert G. M. Bredius,Jennifer M. Puck,Polina Stepensky,Ilhan Tezcan,Katie Rolfe,Erika H. De Boever,Rickey R. Reinhardt,Jonathan Appleby,Fabio Ciceri,Maria Grazia Roncarolo,Alessandro Aiuti +24 more
TL;DR: This investigation investigated the medium-term outcome of gene therapy (GT) in 18 patients with ADA-SCID for whom an HLA-identical family donor was not available; most were not responding well to ERT.
Journal ArticleDOI
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.
Sarah Marktel,Samantha Scaramuzza,Maria Pia Cicalese,Fabio Giglio,Stefania Galimberti,Maria Rosa Lidonnici,Valeria Calbi,Andrea Assanelli,Maria Ester Bernardo,Claudia Rossi,Andrea Calabria,Raffaella Milani,Salvatore Gattillo,Fabrizio Benedicenti,Giulio Spinozzi,Annamaria Aprile,Alessandra Bergami,Miriam Casiraghi,Giulia Consiglieri,Nicoletta Masera,Emanuela D'Angelo,Nadia Mirra,Raffaella Origa,Immacolata Tartaglione,Silverio Perrotta,Robert Winter,Milena Coppola,Gianluca Viarengo,Luca Santoleri,Giovanna Graziadei,Michela Gabaldo,Maria Grazia Valsecchi,Eugenio Montini,Luigi Naldini,Maria Domenica Cappellini,Fabio Ciceri,Alessandro Aiuti,Giuliana Ferrari +37 more
TL;DR: In a phase 1/2 clinical trial, gene therapy with autologous hematopoietic stem cells significantly reduced transfusion requirement in adults and children with transfusion dependent ß-thalassemia.
Journal ArticleDOI
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study
Francesca Ferrua,Maria Pia Cicalese,Stefania Galimberti,Stefania Giannelli,Francesca Dionisio,Federica Barzaghi,Maddalena Migliavacca,Maria Ester Bernardo,Valeria Calbi,Andrea Assanelli,Marcella Facchini,Claudia Fossati,Elena Albertazzi,Samantha Scaramuzza,Immacolata Brigida,Serena Scala,Luca Basso-Ricci,Roberta Pajno,Miriam Casiraghi,Daniele Canarutto,Federica Andrea Salerio,Michael H. Albert,Antonella Bartoli,Hermann M. Wolf,Rossana Fiori,Paolo Silvani,Salvatore Gattillo,Anna Villa,Luca Biasco,Christopher Dott,Emily J. Culme-Seymour,Koenraad van Rossem,Gillian Atkinson,Maria Grazia Valsecchi,Maria Grazia Roncarolo,Fabio Ciceri,Luigi Naldini,Alessandro Aiuti +37 more
TL;DR: Overall survival was 100%.