I
Immacolata Brigida
Researcher at Vita-Salute San Raffaele University
Publications - 37
Citations - 2568
Immacolata Brigida is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Severe combined immunodeficiency. The author has an hindex of 20, co-authored 36 publications receiving 2160 citations. Previous affiliations of Immacolata Brigida include University of Rome Tor Vergata.
Papers
More filters
Journal ArticleDOI
Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency
Alessandro Aiuti,Federica Cattaneo,Stefania Galimberti,Ulrike Benninghoff,Barbara Cassani,Luciano Callegaro,Samantha Scaramuzza,Grazia Andolfi,Massimiliano Mirolo,Immacolata Brigida,Antonella Tabucchi,Filippo Carlucci,Martha M. Eibl,Memet Aker,Shimon Slavin,Hamoud Al-Mousa,Abdulaziz Al Ghonaium,Alina Ferster,Andrea Duppenthaler,Luigi D. Notarangelo,Uwe Wintergerst,Rebecca H. Buckley,Marco Bregni,Sarah Marktel,Maria Grazia Valsecchi,Pier Luca Rossi,Fabio Ciceri,Roberto Miniero,Claudio Bordignon,Claudio Bordignon,Maria Grazia Roncarolo +30 more
TL;DR: Gene therapy, combined with reduced-intensity conditioning, is a safe and effective treatment for SCID in patients with ADA deficiency and effective protection against infections and improvement in physical development made a normal lifestyle possible.
Journal ArticleDOI
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency
Maria Pia Cicalese,Francesca Ferrua,Laura Castagnaro,Roberta Pajno,Federica Barzaghi,Stefania Giannelli,Francesca Dionisio,Immacolata Brigida,Marco Bonopane,Miriam Casiraghi,Antonella Tabucchi,Filippo Carlucci,Eyal Grunebaum,Mehdi Adeli,Robbert G. M. Bredius,Jennifer M. Puck,Polina Stepensky,Ilhan Tezcan,Katie Rolfe,Erika H. De Boever,Rickey R. Reinhardt,Jonathan Appleby,Fabio Ciceri,Maria Grazia Roncarolo,Alessandro Aiuti +24 more
TL;DR: This investigation investigated the medium-term outcome of gene therapy (GT) in 18 patients with ADA-SCID for whom an HLA-identical family donor was not available; most were not responding well to ERT.
Journal ArticleDOI
Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
Kevin Goudy,Didem Aydin,Federica Barzaghi,Eleonora Gambineri,Marina Vignoli,Sara Ciullini Mannurita,Claudio Doglioni,Maurilio Ponzoni,Maria Pia Cicalese,Andrea Assanelli,Alberto Tommasini,Immacolata Brigida,Rosa Maria Dellepiane,Silvana Martino,Sven Olek,Alessandro Aiuti,Fabio Ciceri,Maria Grazia Roncarolo,Rosa Bacchetta +18 more
TL;DR: The complex pathogenesis of CD25 deficiency provides invaluable insight into the role of IL2/IL-2RA-dependent regulation in autoimmunity and inflammatory diseases.
Journal ArticleDOI
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study
Francesca Ferrua,Maria Pia Cicalese,Stefania Galimberti,Stefania Giannelli,Francesca Dionisio,Federica Barzaghi,Maddalena Migliavacca,Maria Ester Bernardo,Valeria Calbi,Andrea Assanelli,Marcella Facchini,Claudia Fossati,Elena Albertazzi,Samantha Scaramuzza,Immacolata Brigida,Serena Scala,Luca Basso-Ricci,Roberta Pajno,Miriam Casiraghi,Daniele Canarutto,Federica Andrea Salerio,Michael H. Albert,Antonella Bartoli,Hermann M. Wolf,Rossana Fiori,Paolo Silvani,Salvatore Gattillo,Anna Villa,Luca Biasco,Christopher Dott,Emily J. Culme-Seymour,Koenraad van Rossem,Gillian Atkinson,Maria Grazia Valsecchi,Maria Grazia Roncarolo,Fabio Ciceri,Luigi Naldini,Alessandro Aiuti +37 more
TL;DR: Overall survival was 100%.
Journal ArticleDOI
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function.
Michael T. Lam,Michael T. Lam,Simona Coppola,Oliver H.F. Krumbach,Giusi Prencipe,Antonella Insalaco,Cristina Cifaldi,Immacolata Brigida,Erika Zara,Serena Scala,Silvia Di Cesare,Simone Martinelli,Martina Di Rocco,Martina Di Rocco,Antonia Pascarella,Marcello Niceta,Francesca Pantaleoni,Andrea Ciolfi,Petra Netter,Alexandre F. Carisey,Alexandre F. Carisey,Michael R. Diehl,Mohammad Akbarzadeh,Francesca Conti,Pietro Merli,Anna Pastore,Stefano Levi Mortera,Serena Camerini,Luciapia Farina,Marcel Buchholzer,Luca Pannone,Tram N. Cao,Zeynep H. Coban-Akdemir,Zeynep H. Coban-Akdemir,Shalini N. Jhangiani,Donna M. Muzny,Richard A. Gibbs,Richard A. Gibbs,Luca Basso-Ricci,Maria Chiriaco,Radovan Dvorsky,Lorenza Putignani,Rita Carsetti,Petra Janning,Asbjørg Stray-Pedersen,Asbjørg Stray-Pedersen,Asbjørg Stray-Pedersen,Hans Christian Erichsen,AnnaCarin Horne,Yenan T. Bryceson,Yenan T. Bryceson,Lamberto Torralba-Raga,Kim Ramme,Vittorio Rosti,Claudia Bracaglia,Virginia Messia,Paolo Palma,Andrea Finocchi,Franco Locatelli,Ivan K. Chinn,James R. Lupski,Emily M. Mace,Caterina Cancrini,Alessandro Aiuti,Mohammad Reza Ahmadian,Jordan S. Orange,Jordan S. Orange,Fabrizio De Benedetti,Marco Tartaglia +68 more
TL;DR: In silico, in vitro, and in vivo analyses are used to correlate the molecular mechanisms altering CDC42 function to the observed phenotype and characterize a novel hematological/autoinflammatory disorder due to a de novo recurrent missense mutation of CDC42.