G
Giulio Spinozzi
Researcher at University of Perugia
Publications - 21
Citations - 351
Giulio Spinozzi is an academic researcher from University of Perugia. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 13 publications receiving 203 citations. Previous affiliations of Giulio Spinozzi include Vita-Salute San Raffaele University & University of Milan.
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Journal ArticleDOI
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.
Sarah Marktel,Samantha Scaramuzza,Maria Pia Cicalese,Fabio Giglio,Stefania Galimberti,Maria Rosa Lidonnici,Valeria Calbi,Andrea Assanelli,Maria Ester Bernardo,Claudia Rossi,Andrea Calabria,Raffaella Milani,Salvatore Gattillo,Fabrizio Benedicenti,Giulio Spinozzi,Annamaria Aprile,Alessandra Bergami,Miriam Casiraghi,Giulia Consiglieri,Nicoletta Masera,Emanuela D'Angelo,Nadia Mirra,Raffaella Origa,Immacolata Tartaglione,Silverio Perrotta,Robert Winter,Milena Coppola,Gianluca Viarengo,Luca Santoleri,Giovanna Graziadei,Michela Gabaldo,Maria Grazia Valsecchi,Eugenio Montini,Luigi Naldini,Maria Domenica Cappellini,Fabio Ciceri,Alessandro Aiuti,Giuliana Ferrari +37 more
TL;DR: In a phase 1/2 clinical trial, gene therapy with autologous hematopoietic stem cells significantly reduced transfusion requirement in adults and children with transfusion dependent ß-thalassemia.
Journal ArticleDOI
Preclinical Testing of the Safety and Tolerability of Lentiviral Vector-Mediated Above-Normal Alpha-L-Iduronidase Expression in Murine and Human Hematopoietic Cells Using Toxicology and Biodistribution Good Laboratory Practice Studies.
Ilaria Visigalli,Stefania Delai,Francesca Ferro,Francesca Cecere,Michela Vezzoli,Francesca Sanvito,Franck Chanut,Fabrizio Benedicenti,Giulio Spinozzi,Rob Wynn,Andrea Calabria,Luigi Naldini,Eugenio Montini,Patrizia Cristofori,Alessandra Biffi +14 more
TL;DR: Biosafety studies were conducted to assess the toxicity and tumorigenic potential, as well as the biodistribution of HSCs and progenitor cells transduced with lentiviral vectors encoding the cDNA of the alpha-iduronidase (IDUA) gene, which is mutated in MPS I patients.
Journal ArticleDOI
VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites.
Andrea Calabria,Simone Leo,Simone Leo,Fabrizio Benedicenti,Daniela Cesana,Giulio Spinozzi,Massimilano Orsini,Stefania Merella,Elia Stupka,Gianluigi Zanetti,Eugenio Montini +10 more
TL;DR: This paper developed VISPA (Vector Integration Site Parallel Analysis), a pipeline for automated integration site identification and annotation based on a distributed environment with a simple Galaxy web interface, which was successfully used for the bioinformatics analysis of the follow-up of two lentiviral vector-based hematopoietic stem-cell gene therapy clinical trials.
Journal ArticleDOI
VISPA2: a scalable pipeline for high-throughput identification and annotation of vector integration sites.
Giulio Spinozzi,Andrea Calabria,Stefano Brasca,Stefano Beretta,Ivan Merelli,Luciano Milanesi,Eugenio Montini +6 more
TL;DR: These performances indicate that VISPA2 is a fast, reliable and user-friendly tool for integration site analysis, which allows gene therapy integration data to be handled in a cost and time effective fashion.
Journal ArticleDOI
Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML
Ilaria Gionfriddo,Lorenzo Brunetti,Federica Mezzasoma,Francesca Milano,Valeria Cardinali,Roberta Ranieri,Alessandra Venanzi,Sara Pierangeli,Calogero Vetro,Giulio Spinozzi,Erica Dorillo,Hsin-Chieh Wu,Caroline Berthier,Raffaella Ciurnelli,MJ Griffin,Claire E. Jennings,Enrico Tiacci,Paolo Sportoletti,Franca Falzetti,Gareth J. Veal,Maria Paola Martelli,Brunangelo Falini +21 more
TL;DR: In this paper, the safety and efficacy of single-agent dactinomycin in relapsed/refractory NPM1-mutated adult AML patients were investigated.