M
MK Chung
Researcher at The Chinese University of Hong Kong
Publications - 23
Citations - 593
MK Chung is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Zona pellucida & Pregnancy. The author has an hindex of 11, co-authored 19 publications receiving 554 citations. Previous affiliations of MK Chung include University of Hong Kong.
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Journal ArticleDOI
Glycodelin-S in Human Seminal Plasma Reduces Cholesterol Efflux and Inhibits Capacitation of Spermatozoa
Philip C.N. Chiu,MK Chung,Heng-Yan Tsang,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Kai-Fai Lee,William S.B. Yeung +7 more
TL;DR: Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa, indicating that the carbohydrate moiety of glycodelin -S is critical for the function of the molecule.
Journal ArticleDOI
Effects of Native Human Zona Pellucida Glycoproteins 3 and 4 on Acrosome Reaction and Zona Pellucida Binding of Human Spermatozoa
Philip C.N. Chiu,Ben S.T. Wong,MK Chung,Kevin K.W. Lam,Ronald T.K. Pang,Kai-Fai Lee,Sutiman Bambang Sumitro,Satish K. Gupta,William S.B. Yeung +8 more
TL;DR: The actions of purified native human ZP3 and ZP4 on acrosome reaction and spermatozoa-ZP binding are described for the first time.
Journal ArticleDOI
Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding.
Philip C.N. Chiu,MK Chung,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Pak Chung Ho,Ernest Hung Yu Ng,Kai-Fai Lee,William S.B. Yeung +8 more
TL;DR: Observations suggest that human sperm FUT5 is a receptor of glycodelin-A and zona pellucida proteins, and that glycodzin-A inhibits spermatozoa-zona binding by blocking the binding of sperm Fut5 to the zonapellucIDA.
Journal ArticleDOI
Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding.
Philip C.N. Chiu,MK Chung,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Pak Chung Ho,Ernest Hung Yu Ng,Kai-Fai Lee,William S.B. Yeung +8 more
TL;DR: Glycodelin-C stimulated spermatozoazona pellucida binding in a dose-dependent manner, and it effectively displaced sperm-bound gly codelin-A and -F and enhances the zona binding capacity of spermatozosa passing through the cumulus oophorus.
Journal ArticleDOI
Effects of Differential Glycosylation of Glycodelins on Lymphocyte Survival
Cheuk-Lun Lee,Poh-Choo Pang,William S.B. Yeung,Bérangère Tissot,Maria Panico,Terence T. Lao,Ivan K. Chu,Kai-Fai Lee,MK Chung,Kevin K.W. Lam,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Howard R. Morris,Anne Dell,Philip C.N. Chiu +15 more
TL;DR: Both GdA and GdF inhibited the proliferation, induced cell death, and suppressed interleukin-2 secretion of Jurkat cells and peripheral blood mononuclear cells, and no immunosuppressive effect was observed for GdS andGdC.