Glycodelin-S in Human Seminal Plasma Reduces Cholesterol Efflux and Inhibits Capacitation of Spermatozoa
Philip C.N. Chiu,MK Chung,Heng-Yan Tsang,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Kai-Fai Lee,William S.B. Yeung +7 more
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TLDR
Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa, indicating that the carbohydrate moiety of glycodelin -S is critical for the function of the molecule.About:
This article is published in Journal of Biological Chemistry.The article was published on 2005-07-08 and is currently open access. It has received 98 citations till now. The article focuses on the topics: Glycodelin & Capacitation.read more
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Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida.
Poh-Choo Pang,Philip C.N. Chiu,Cheuk-Lun Lee,Lan-Yi Chang,Maria Panico,Howard R. Morris,Stuart M. Haslam,Kay-Hooi Khoo,Gary F. Clark,William S.B. Yeung,Anne Dell +10 more
TL;DR: In this paper, the sialyl-Lewis(x) sequence [NeuAcα2-3Galβ1-4(Fucα1-3)GlcNAc], a well-known selectin ligand, is the most abundant terminal sequence on the N- and O-glycans of human ZP.
Atlas of Genetics and Cytogenetics in Oncology and Haematology
TL;DR: WWTR1 (also called TAZ in publications) is a WW domaing-containing transcriptional coactivator, which was first identified as a 14-3-3 binding protein that is involved in mesenchymal stem cell differentiation as well as tumorigenesis.
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Factors Regulating Sperm Capacitation
TL;DR: The challenges of studying capacitation are discussed and recent notions regarding its regulation are summarized to summarized to fully characterize additional signaling mediators such as phosphatases and other kinases that may be involved.
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Semenogelin, the main protein of the human semen coagulum, regulates sperm function.
TL;DR: Experimental evidence demonstrates that prostate-specific antigen (PSA) rapidly cleaves Sg, an event temporally associated with semen liquefaction and initiation of sperm motility, which could play important role in preventing premature capacitation.
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Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations
TL;DR: This review updates the recent research and clinical associations of glycodelin and highlights the role of glycosylation, which may be involved in the protection of spermatozoa against maternal immune reactions, and glyCodelin also has apoptogenic activity.
References
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TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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TL;DR: This laboratory manual consists of 2 sections which describe methods of examination of human semen and semen-cervical mucus interaction in order to standardize procedures and facilitate evaluation and comparison of research reports.
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Invited Review: β-Lactoglobulin: Binding Properties, Structure, and Function
TL;DR: It is proposed that β -LG, over-expressed in the lactating mammary gland of many, but not all, species, is primarily an important source of amino acids for the offspring of those animals that produce it, but that this function arose by gene duplication from the physiologically essential glycodelin.
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Cyclic adenosine 3',5'monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility.
TL;DR: Results suggest that divergent pathways might regulate tyrosine phosphorylation of p105 and p81 and sperm capacitation after cAMP-dependent phosphorylations of an intermediate protein, and suggest that protein phosphatase PP1 is involved in the two latter phenomena while PP2A mediates sperm capacitations.