Mohan Viswanathan

TL;DR: The data suggest that augmenting mitochondrial stress signaling through the modulation of NAD(+) levels may be a target to improve mitochondrial function and prevent or treat age-associated decline.

TL;DR: These findings demonstrate that abu-11 and other members of its ER stress gene family are positive determinants of C. elegans life span and that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes.

TL;DR: The existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 act in parallel to the insulin-like pathway to activate DAF-16 and extend life span is proposed.

TL;DR: The first metazoan Sir2 homologue shown to affect lifespan, Caenorhabditis elegans sir-2.1, was identified and the extension of lifespan was overestimated in a high-copy sir- 2.1 transgene-containing worm strain because of an unlinked mutation.

TL;DR: The isolation and characterization of smn-1(cb131), a novel allele encoding a substitution in a highly conserved residue of exon 2, resembling a point mutation found in a patient with type IIIb SMA is reported, which may assist in accelerating the development of drugs for the treatment of SMA.