Y
Young Suk Jo
Researcher at Yonsei University
Publications - 97
Citations - 3667
Young Suk Jo is an academic researcher from Yonsei University. The author has contributed to research in topics: Thyroid cancer & Papillary thyroid cancer. The author has an hindex of 27, co-authored 92 publications receiving 3107 citations. Previous affiliations of Young Suk Jo include Eulji University & Chungnam National University.
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Journal ArticleDOI
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laurent Mouchiroud,Riekelt H. Houtkooper,Norman Moullan,Elena Katsyuba,Dongryeol Ryu,Carles Cantó,Adrienne Mottis,Young Suk Jo,Mohan Viswanathan,Kristina Schoonjans,Leonard Guarente,Johan Auwerx +11 more
TL;DR: The data suggest that augmenting mitochondrial stress signaling through the modulation of NAD(+) levels may be a target to improve mitochondrial function and prevent or treat age-associated decline.
Journal ArticleDOI
An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases.
Dong Wook Kim,Young Suk Jo,Hye Sook Jung,Hyo Kyun Chung,Jung Hun Song,Ki Cheol Park,Su Hyeon Park,Jung Hwan Hwang,So Young Rha,Gi Ryang Kweon,Su Jae Lee,Kiwon Jo,Minho Shong +12 more
TL;DR: SU11248 is a highly effective tyrosine kinase inhibitor of the RET/PTC oncogenic kinase.
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Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
Eija Pirinen,Eija Pirinen,Eija Pirinen,Carles Cantó,Young Suk Jo,Laia Morató,Hongbo Zhang,Keir J. Menzies,Evan G. Williams,Laurent Mouchiroud,Norman Moullan,Carolina E. Hagberg,Carolina E. Hagberg,Wei Li,Silvie Timmers,Silvie Timmers,Ralph Imhof,Jef Verbeek,Jef Verbeek,Aurora Pujol,Barbara van Loon,Carlo Viscomi,Massimo Zeviani,Patrick Schrauwen,Anthony A. Sauve,Kristina Schoonjans,Johan Auwerx +26 more
TL;DR: Tight negative correlation between Parp-1 expression and energy expenditure in heterogeneous mouse populations is shown, indicating that variations in PARP-1 activity have an impact on metabolic homeostasis and can be translated into pharmacological applications.
Journal ArticleDOI
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.
Dongryeol Ryu,Young Suk Jo,Young Suk Jo,Giuseppe Lo Sasso,Sokrates Stein,Hongbo Zhang,Alessia Perino,Jung Uee Lee,Massimo Zeviani,Raymond Romand,Michael O. Hottiger,Kristina Schoonjans,Johan Auwerx +12 more
TL;DR: Data suggest that SIRT7 is a dynamic nuclear regulator of mitochondrial function through its impact on GABPβ1 function, a master regulator of nuclear-encoded mitochondrial genes.
Journal ArticleDOI
Influence of the BRAF V600E Mutation on Expression of Vascular Endothelial Growth Factor in Papillary Thyroid Cancer
Young Suk Jo,Shengjin Li,Jung Hun Song,Ki Hyun Kwon,Jun Chul Lee,So Young Rha,Hyo Jin Lee,Ji Young Sul,Gi Ryang Kweon,Heung-kyu Ro,Jin-Man Kim,Minho Shong +11 more
TL;DR: The relatively high levels of VEGF expression may be related to poorer clinical outcomes and recurrences in BRAF V600E(+) PTC, which tended to have larger tumor volumes and higher expression of V EGF.