M
Mary K. Kennedy
Researcher at Northwestern University
Publications - 31
Citations - 5139
Mary K. Kennedy is an academic researcher from Northwestern University. The author has contributed to research in topics: T cell & Encephalomyelitis. The author has an hindex of 21, co-authored 30 publications receiving 5036 citations. Previous affiliations of Mary K. Kennedy include University of Chicago.
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Journal ArticleDOI
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
Mary K. Kennedy,Moira Glaccum,Sandra N. Brown,Eric A. Butz,Joanne L. Viney,Monica E. Embers,Naoto Matsuki,Keith Charrier,Lisa M. Sedger,Cynthia R. Willis,Kenneth Brasel,Philip J. Morrissey,Kim L. Stocking,JoAnn C. L. Schuh,Sebastian Joyce,Jacques J. Peschon +15 more
TL;DR: Critical roles for IL-15 in the development of specific lymphoid lineages are revealed and the ability to rescue lymphoid defects inIL-15−/− mice by IL- 15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine.
Journal Article
Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.
TL;DR: It is suggested that local cytokine production varies significantly during the course of EAE and that increases in discrete sets of cytokines are associated with the acute response and the recovery/chronic phase of disease.
Journal ArticleDOI
Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells
Ananda W. Goldrath,Pallavur V. Sivakumar,Moira Glaccum,Mary K. Kennedy,Michael J. Bevan,Christophe Benoist,Diane Mathis,Eric A. Butz +7 more
TL;DR: The results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memoryT lymphocytes have distinct requirements for proliferation in full versus empty compartments.
Journal ArticleDOI
Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death
Fred Ramsdell,Michael S. Seaman,Robert E. Miller,Kathleen S. Picha,Mary K. Kennedy,David H. Lynch +5 more
TL;DR: The Fas/Fas-L pathway appears to be critical for the induction of AICD and this pathway is differentially regulated in cells committed to either Th1 or Th2 differentiation.
Journal ArticleDOI
CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major
Campbell Kim A,Pamela J. Ovendale,Mary K. Kennedy,William C. Fanslow,Steven G. Reed,Charles R. Maliszewski +5 more
TL;DR: A protective cell-mediated immune response to L. major appears to be dependent upon CD40L-induced IL-12 secretion by antigen-presenting cells, as assessed by assessing the course of Leishmania major infection inCD40L knockout mice that were generated on a resistant background.