K
Kim L. Stocking
Researcher at University of North Carolina at Chapel Hill
Publications - 7
Citations - 9849
Kim L. Stocking is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: ADAM17 Protein & Cytotoxic T cell. The author has an hindex of 7, co-authored 7 publications receiving 9478 citations.
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Journal ArticleDOI
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Roy A. Black,Charles Rauch,Carl J. Kozlosky,Jacques J. Peschon,Jennifer L. Slack,Martin F. Wolfson,Beverly J. Castner,Kim L. Stocking,Pranitha Reddy,Subhashini Srinivasan,Nicole Nelson,Norman Boiani,Kenneth A. Schooley,Mary Gerhart,Raymond Davis,Jeffrey N. Fitzner,Richard S. Johnson,Raymond J. Paxton,Carl J. March,Douglas P. Cerretti +19 more
TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.
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An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
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Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
Mary K. Kennedy,Moira Glaccum,Sandra N. Brown,Eric A. Butz,Joanne L. Viney,Monica E. Embers,Naoto Matsuki,Keith Charrier,Lisa M. Sedger,Cynthia R. Willis,Kenneth Brasel,Philip J. Morrissey,Kim L. Stocking,JoAnn C. L. Schuh,Sebastian Joyce,Jacques J. Peschon +15 more
TL;DR: Critical roles for IL-15 in the development of specific lymphoid lineages are revealed and the ability to rescue lymphoid defects inIL-15−/− mice by IL- 15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine.
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Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
Peng Ye,Fred H. Rodriguez,Suzanne T. Kanaly,Kim L. Stocking,Jill R. Schurr,Paul Schwarzenberger,Peter Oliver,Weitao Huang,Ping Zhang,Jason Zhang,Judd E. Shellito,G. J. Bagby,Steve Nelson,Keith Charrier,Jacques J. Peschon,Jay K. Kolls +15 more
TL;DR: Impaired IL-17R signaling is supported as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia.
Journal ArticleDOI
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.
Hilary J. McKenna,Kim L. Stocking,Robert E. Miller,Kenneth Brasel,Thibaut De Smedt,Eugene Maraskovsky,Charles R. Maliszewski,David H. Lynch,Jeffrey B. Smith,Bali Pulendran,Eileen R. Roux,Mark Teepe,Stewart D. Lyman,Jacques J. Peschon +13 more
TL;DR: It is concluded that flt3L has an important role in the expansion of early hematopoietic progenitors and in the generation of mature peripheral leukocytes.