Laura Strittmatter

TL;DR: Genome phylogenetic profiling, genome-wide RNA co-expression analysis and organelle-wide protein coexpression analysis are used to predict proteins functionally related to MICU1, establishing MCU as an essential component of the mitochondrial Ca2+ uniporter.

TL;DR: This study compares messenger RNA profiles of 1,454 metabolic enzymes across 1,981 tumours spanning 19 cancer types to identify enzymes that are consistently differentially expressed and highlights the importance of mitochondrial compartmentalization of one-carbon metabolism in cancer and raises important therapeutic hypotheses.

TL;DR: The results identify MICU2 as a new component of the uniporter complex that may contribute to the tissue-specific regulation of this channel, and provide multiple lines of biochemical evidence that MCU, MICU1 andMICU2 reside within a complex and cross-stabilize each other's protein expression in a cell-type dependent manner.

TL;DR: This study identifies systemic, metabolic pathway derangements that can lie downstream of primary mitochondrial lesions, with implications for understanding how the organelle contributes to rare and common diseases.

TL;DR: Global metabolic profiling and follow-up studies in patient-derived fibroblasts reveal defects in bile acid conjugation and lipid metabolism, pathways that require coenzyme A, raising a novel therapeutic hypothesis, namely, that dietary fats and bile Acid supplements may hold potential as disease-modifying interventions.