M
Molly R. Perkins
Researcher at National Institutes of Health
Publications - 13
Citations - 1387
Molly R. Perkins is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Simian immunodeficiency virus. The author has an hindex of 8, co-authored 12 publications receiving 1233 citations. Previous affiliations of Molly R. Perkins include Vaccine Research Center.
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Journal ArticleDOI
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
Tom Wilkinson,Li Ckf.,Chui Csc.,Huang Aky.,Huang Aky.,Molly R. Perkins,Julia C. Liebner,Rob Lambkin-Williams,Anthony Gilbert,J. Oxford,Ben Nicholas,Karl J. Staples,Tao Dong,Daniel C. Douek,Andrew J. McMichael,Xiao-Ning Xu +15 more
TL;DR: Inf influenza infection studies in healthy volunteers with no detectable antibodies to the challenge viruses H3N2 or H1N1 are conducted, finding a large increase in influenza-specific T cell responses by day 7, when virus was completely cleared from nasal samples and serum antibodies were still undetectable.
Journal ArticleDOI
Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
Nichole R. Klatt,Lauren A. Canary,Xiaoyong Sun,Carol L. Vinton,Nicholas T. Funderburg,David R. Morcock,Mariam Quinones,Clayton Deming,Molly R. Perkins,Daria J. Hazuda,Michael D. Miller,Michael M. Lederman,Julie A. Segre,Jeffrey D. Lifson,Elias K. Haddad,Jacob D. Estes,Jason M. Brenchley +16 more
TL;DR: ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.
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Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells
Nina Calantone,Fan Wu,Zachary Klase,Claire Deleage,Molly R. Perkins,Kenta Matsuda,Elizabeth A. Thompson,Alexandra M. Ortiz,Carol L. Vinton,Ilnour Ourmanov,Karin Loré,Karin Loré,Daniel C. Douek,Jacob D. Estes,Vanessa M. Hirsch,Jason M. Brenchley +15 more
TL;DR: It is suggested that myeloid cells are not a major source of SIV in vivo, irrespective of Vpx expression, and their viral DNA may be attributed to phagocytosis of Siv-infected T cells.
Journal ArticleDOI
IL-21 and Probiotic Therapy Improve TH17 Frequencies, Microbial Translocation, and Microbiome in ARV-Treated, SIV-Infected Macaques
Alexandra M. Ortiz,Zachary Klase,Zachary Klase,Sarah R. DiNapoli,Ivan Vujkovic-Cvijin,Kirby Carmack,Molly R. Perkins,Nina Calantone,Carol L. Vinton,Nadeene E. Riddick,John R. Gallagher,Nichole R. Klatt,Nichole R. Klatt,Joseph M. McCune,Jacob D. Estes,Mirko Paiardini,Jason M. Brenchley +16 more
TL;DR: It is proposed that combining ARVs with therapeutics aimed at restoring intestinal stasis may significantly improve disease prognosis of ARV-treated, HIV-infected individuals.
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JC virus in CD34+ and CD19+ cells in patients with multiple sclerosis treated with natalizumab.
Elliot M. Frohman,Maria Chiara Monaco,Gina Remington,Caroline F. Ryschkewitsch,Peter N. Jensen,Kory R. Johnson,Molly R. Perkins,Julia C. Liebner,Benjamin Greenberg,Nancy L. Monson,Teresa C. Frohman,Daniel C. Douek,Eugene O. Major +12 more
TL;DR: JC virus DNA was detectable within cell compartments of natalizumab-treated MS patients after treatment inception and longer, and these data link the mechanism of natazumab treatment with progressive multifocal leukoencephalopathy.